Gwosdow A R, Besch E L, Chen C L, Li W I
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(2):269-72. doi: 10.1016/0742-8413(85)90161-6.
Endocrine and thermoregulatory responses were studied in male rats exposed to heat (32.5 +/- 0.1 degrees C) from acclimation temperatures of either 24.5 +/- 0.1 degrees C or 29.2 +/- 0.1 degrees C. After 1 hr in the heat, evaporative water loss and tail skin temperature changes in the 24.5 degrees C acclimated rats were greater than in the 29.2 degrees C acclimated rats; both groups displayed similar changes in metabolic rate and rectal temperature. At the respective acclimation temperatures, 29.2 degrees C rats displayed lowered plasma thyroid hormones, elevated beta-endorphin-like immunoreactivity (beta-END-LI) in the plasma, neurointermediate and anterior lobes of the pituitary gland, and no change in plasma corticosterone levels compared to 24.5 degrees C rats. After exposure to 32.5 degrees C for 1 hr, both groups of rats maintained similar plasma corticosterone levels; however, only the 24.5 degrees C group increased plasma thyroxine and beta-END-LI. These data suggest that beta-endorphin may be involved in body temperature regulation during acclimation to elevated environmental temperatures.
对从24.5±0.1℃或29.2±0.1℃的适应温度暴露于热环境（32.5±0.1℃）的雄性大鼠的内分泌和体温调节反应进行了研究。在热环境中暴露1小时后，24.5℃适应组大鼠的蒸发失水量和尾部皮肤温度变化大于29.2℃适应组大鼠；两组大鼠的代谢率和直肠温度变化相似。在各自的适应温度下，与24.5℃适应组大鼠相比，29.2℃适应组大鼠的血浆甲状腺激素水平降低，血浆、垂体神经中间叶和前叶中的β-内啡肽样免疫反应性（β-END-LI）升高，血浆皮质酮水平无变化。在暴露于32.5℃1小时后，两组大鼠的血浆皮质酮水平维持相似；然而，只有24.5℃适应组大鼠的血浆甲状腺素和β-END-LI升高。这些数据表明，β-内啡肽可能参与了适应环境温度升高期间的体温调节。
