Zis Panagiotis, Varrassi Giustino
Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Department of Neurology, University of Sheffield, Sheffield, UK.
Pain Ther. 2017 Dec;6(2):115-116. doi: 10.1007/s40122-017-0077-2. Epub 2017 Jul 1.
Peripheral neuropathy (PN) is very prevalent in cancer patients and a leading cause of pain related to cancer. However, the underlying pathophysiological mechanisms vary significantly. Peripheral neuropathy can be a direct or an indirect complication of cancer or cancer-related treatment, or a pre-existing comorbidity not related to cancer. PN might also occur as a paraneoplastic neurological syndrome. Such syndromes are immune-mediated manifestations that usually precede the diagnosis of cancer or cancer's relapse. Pain is very prevalent in paraneoplastic peripheral neuropathies and, therefore, merits attention.
周围神经病变（PN）在癌症患者中非常普遍，是癌症相关疼痛的主要原因。然而，其潜在的病理生理机制差异很大。周围神经病变可能是癌症或癌症相关治疗的直接或间接并发症，也可能是与癌症无关的既往合并症。PN也可能作为副肿瘤性神经综合征出现。这些综合征是免疫介导的表现，通常先于癌症诊断或癌症复发出现。疼痛在副肿瘤性周围神经病变中非常普遍，因此值得关注。
