Michaelides Athena, Hadden Robert D M, Sarrigiannis Ptolemaios G, Hadjivassiliou Marios, Zis Panagiotis
Medical School, University of Nicosia, Nicosia, Cyprus.
Department of Neurology, King's College Hospital, London, UK.
Pain Ther. 2019 Dec;8(2):177-185. doi: 10.1007/s40122-019-0128-y. Epub 2019 Jun 14.
Although chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) predominantly affects large myelinated fibers, many patients have pain. The aim of this paper is to systematically review the current literature regarding CIDP with a particular focus on epidemiological and clinical characteristics of painful CIDP.
A systematic literature search was conducted on PubMed database.
Our search strategy identified 146 articles. Thirty-eight papers, reporting on 991 patients, met the inclusion criteria and were used for this review. The pooled estimate of the prevalence of pain at any point within the course of CIDP was 46% (95% CI 36-57%). Immune treatment of CIDP might be adequate as monotherapy for the management of pain. Treatment specific to pain currently shows effectiveness as adjuvant treatment when CIDP is treated and pain persists.
Pain in CIDP is an underexplored field. Future research should focus on the natural history, phenomenology, and management of pain in CIDP.
尽管慢性炎性脱髓鞘性多发性神经根神经病（CIDP）主要影响大的有髓纤维，但许多患者会出现疼痛。本文旨在系统回顾当前关于CIDP的文献，特别关注疼痛性CIDP的流行病学和临床特征。
在PubMed数据库中进行了系统的文献检索。
我们的检索策略共识别出146篇文章。38篇报道了991例患者的文章符合纳入标准，并用于本综述。CIDP病程中任何时间点疼痛患病率的汇总估计为46%（95%可信区间36 - 57%）。CIDP的免疫治疗作为疼痛管理的单一疗法可能是足够的。当CIDP接受治疗且疼痛持续时，目前针对疼痛的特异性治疗作为辅助治疗显示出有效性。
CIDP中的疼痛是一个未被充分探索的领域。未来的研究应聚焦于CIDP疼痛的自然史、现象学和管理。
