Fathi M M, Asaad A M
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;83(1):185-90. doi: 10.1016/0742-8413(86)90034-4.
The total ACh content and AChE activity were determined 1 hr after the i.p. injection of different doses of thiopental sodium (5, 10 and 20 mg/ml/100 g body wt) and barbitone sodium (20, 40 and 80 mg/ml/100 g body wt). The effect of different time intervals (1 min, 10 min, 30 min, 1 hr, 2.5 hr, 5 hr, 8 hr, 12 hr, 24 hr and 48 hr) on the total ACh content and AChE activity was investigated after i.p. injection of 10 mg thiopental sodium and 40 mg barbitone sodium/ml/100 g body wt. Both thiopental sodium and barbitone sodium increased the total ACh content in the brain tissue of Arvicanthis niloticus. Both drugs inhibited the brain AChE activity. It is thought that the increase in the total ACh content in the brain tissue of Arvicanthis niloticus may be due to a decrease in the release of ACh from the neuronal tissue and a decrease in AChE activity.
腹腔注射不同剂量的硫喷妥钠（5、10和20毫克/毫升/100克体重）和巴比妥钠（20、40和80毫克/毫升/100克体重）1小时后，测定总乙酰胆碱（ACh）含量和乙酰胆碱酯酶（AChE）活性。腹腔注射10毫克硫喷妥钠和40毫克巴比妥钠/毫升/100克体重后，研究不同时间间隔（1分钟、10分钟、30分钟、1小时、2.5小时、5小时、8小时、12小时、24小时和48小时）对总ACh含量和AChE活性的影响。硫喷妥钠和巴比妥钠均增加了尼罗多齿鼠脑组织中的总ACh含量。两种药物均抑制脑AChE活性。据认为，尼罗多齿鼠脑组织中总ACh含量的增加可能是由于神经组织中ACh释放减少和AChE活性降低所致。
