Nemirovskiĭ A Iu
Farmakol Toksikol. 1985 Sep-Oct;48(5):36-9.
Two series of experiments were performed to study the effects of oxotremorine (5, 10 and 20 micrograms/kg), arecoline (0.25, 0.5 and 1.0 mg/kg), pilocarpine (5, 10 and 20 mg/kg) and aceclidine (0.25, 0.5 and 1.0 mg/kg) injected intravenously on nociceptive transmission in the spinal cord of spinal rats. It was established that the m-cholinomimetics inhibit in a dose-dependent manner the nociceptive reflex induced by intraarterial injection of bradykinin. When given in the same doses the drugs reduce the bradykinin-induced bioelectrical activity in the afferent tracts of the spinal cord. Atropine (1 mg/kg i. v.) abolishes the antinociceptive action of the cholinomimetics.
进行了两组实验，以研究静脉注射氧化震颤素（5、10和20微克/千克）、槟榔碱（0.25、0.5和1.0毫克/千克）、毛果芸香碱（5、10和20毫克/千克）和醋克利定（0.25、0.5和1.0毫克/千克）对脊髓大鼠脊髓中伤害性传递的影响。已确定M胆碱能拟似药以剂量依赖性方式抑制动脉内注射缓激肽诱导的伤害性反射。当给予相同剂量时，这些药物可降低缓激肽诱导的脊髓传入束生物电活动。阿托品（1毫克/千克静脉注射）可消除胆碱能拟似药的抗伤害作用。
