Kharkevich D A
Department of Pharmacology, First Moscow Medical Institute, USSR.
Ann Ist Super Sanita. 1990;26(1):11-5.
The effect of the agents with muscarinomimetic activity on the nociceptive transmission in the spinal cord was studied in spinal rats. Oxotremorine (5-20 micrograms/kg, i.v.), arecoline (0.25-1.0 mg/kg, i.v.), pilocarpine (5-20 mg/kg, i.v.) and aceclidine (0.25-1.0 mg/kg, i.v.) inhibited the nociceptive flexor reflex induced by intraarterial injection of bradykinin. Muscarinomimetics in the same doses and anticholinesterase agents physostigmine (1-4 micrograms, intrathecally) and galanthamine (25-100 micrograms, intrathecally) inhibited bradykinin-induced bioelectric activity in the spinal ventrolateral tracts. Atropine (1 mg/kg, i.v.) abolished the inhibitory effect of the agents tested on the nociceptive flexor reflex and bioelectric activity.
在脊髓损伤大鼠中研究了具有拟毒蕈碱活性的药物对脊髓伤害性信息传递的影响。氧化震颤素（5 - 20微克/千克，静脉注射）、槟榔碱（0.25 - 1.0毫克/千克，静脉注射）、毛果芸香碱（5 - 20毫克/千克，静脉注射）和醋克利定（0.25 - 1.0毫克/千克，静脉注射）抑制了动脉内注射缓激肽所诱导的伤害性屈肌反射。相同剂量的拟毒蕈碱药物以及抗胆碱酯酶药物毒扁豆碱（1 - 4微克，鞘内注射）和加兰他敏（25 - 100微克，鞘内注射）抑制了缓激肽诱导的脊髓腹外侧束生物电活动。阿托品（1毫克/千克，静脉注射）消除了所测试药物对伤害性屈肌反射和生物电活动的抑制作用。
