Spätling L, Neuman M R, Huch R, Huch A
Int J Gynaecol Obstet. 1985 Oct;23(5):369-76. doi: 10.1016/0020-7292(85)90145-6.
The softening effect of prostaglandin (PG) on cervical tissue prior to elective pregnancy termination is quantified by a new technique for the measurement of the elastance and relaxation of the cervix. The method is based on the pressure-volume relation of a compliant balloon placed in the cervical canal. These properties have been measured before and after different applications of prostaglandins in 58 patients electively terminating pregnancy. Application techniques used included high pressure jet application of PGE2 into the tissue of the portio uteri and the internal cervical os (120 micrograms), PGE2 and PGF2 alpha in Tylose gel (100 micrograms/0.5 ml); PGE2 as an intracervical tablet (150 micrograms) and PGE2 oral tablets placed into the posterior fornix of the vagina. Significant changes in cervical elastance were seen with the intracervically applied PGE2 in Tylose gel and the vaginally applied PGE2 tablets. The intracervically applied PGE2 gel also gave significant changes in cervical relaxation. No side effects other than mild cramping (2 patients) were seen with any of the applications in this study.
通过一种测量宫颈弹性和松弛度的新技术，对前列腺素（PG）在选择性终止妊娠前对宫颈组织的软化作用进行了量化。该方法基于放置在宫颈管内的顺应性球囊的压力-容积关系。在58例选择性终止妊娠的患者中，在不同前列腺素应用前后测量了这些特性。使用的应用技术包括将PGE2高压喷射到子宫颈外口和子宫颈内口组织中（120微克），在泰洛糖凝胶中使用PGE2和PGF2α（100微克/0.5毫升）；将PGE2作为宫颈内片剂（150微克）以及将PGE2口服片剂放入阴道后穹窿。宫颈内应用泰洛糖凝胶中的PGE2和阴道内应用PGE2片剂后，宫颈弹性有显著变化。宫颈内应用PGE2凝胶也使宫颈松弛有显著变化。本研究中任何一种应用除了2例出现轻度痉挛外，未观察到其他副作用。
