Wang Xu, Ouyang Fengxiu, Feng Liping, Wang Xia, Liu Zhiwei, Zhang Jun
MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA.
Environ Health Perspect. 2017 Jun 27;125(6):067017. doi: 10.1289/EHP500.
Triclosan (TCS) is a synthetic antibacterial chemical widely used in personal care products. TCS exposure has been associated with decreased thyroid hormone levels in animals, but human studies are scarce and controversial.
We evaluated the association between maternal TCS exposure and thyroid hormone levels of mothers and newborns.
TCS was measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) in urine samples collected during gestational weeks 38.8±1.1 from 398 pregnant women in a prospective birth cohort enrolled in 2012-2013 in Shanghai, China. Maternal serum levels of free thyroxine (FT), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb) were obtained from medical records. Cord blood levels of free triiodothyronine (FT), FT, TSH, and TPOAb were measured. Multiple linear and logistic regression models were used to examine the relationship between maternal urinary TCS and thyroid hormone levels.
TCS was detectable (≥0.1 ng/mL) in 98.24% of maternal urine samples with tertile of urinary TCS levels: low (>0.1-2.75 μg/g.Cr), medium (2.75–9.78 μg/g.Cr), and high (9.78–427.38 μg/g.Cr). With adjustment for potential confounders, cord blood log(FT)pmol/L concentration was 0.11 lower in newborns of mothers with medium and high urinary TCS levels compared with those with low levels. At third trimester, the high TCS concentration was associated with 0.03 [95% confidence interval (CI) −0.08, −0.02] lower maternal serum log(FT)pmol/L, whereas the medium TCS concentration was associated with 0.15 (95% CI: −0.28, −0.03) lower serum log(TSH)mIU/L with adjustment for covariates.
Our results suggest significant inverse associations between maternal urinary TCS and cord blood FT as well as maternal blood FT concentrations at third trimester. https://doi.org/10.1289/EHP500.
三氯生（TCS）是一种广泛用于个人护理产品的合成抗菌化学物质。动物实验表明，接触TCS与甲状腺激素水平降低有关，但人体研究较少且存在争议。
我们评估了孕妇接触TCS与母亲及新生儿甲状腺激素水平之间的关联。
采用高效液相色谱-串联质谱法（HPLC-MS/MS）测定了2012年至2013年在中国上海招募的398名孕妇前瞻性出生队列中，孕38.8±1.1周时采集的尿液样本中的TCS。从医疗记录中获取母亲血清游离甲状腺素（FT）、促甲状腺激素（TSH）和甲状腺过氧化物酶抗体（TPOAb）水平。测量脐血中游离三碘甲状腺原氨酸（FT）、FT、TSH和TPOAb水平。使用多元线性和逻辑回归模型来检验孕妇尿中TCS与甲状腺激素水平之间的关系。
98.24%的孕妇尿液样本中可检测到TCS（≥0.1 ng/mL），尿中TCS水平分为三个三分位数：低（>0.1-2.75 μg/g.Cr）、中（2.75–9.78 μg/g.Cr）和高（9.78–427.38 μg/g.Cr）。在调整潜在混杂因素后，尿中TCS水平为中、高的母亲所生新生儿的脐血log(FT)pmol/L浓度比低水平母亲所生新生儿低0.11。在孕晚期，高TCS浓度与母亲血清log(FT)pmol/L降低0.03 [95%置信区间（CI）−0.08，−0.02]相关，而中TCS浓度与调整协变量后血清log(TSH)mIU/L降低0.15（95% CI：−0.28，−0.03）相关。
我们的结果表明，孕妇尿中TCS与脐血FT以及孕晚期母亲血FT浓度之间存在显著的负相关。https://doi.org/10.1289/EHP500。
