Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, United States.
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Horm Behav. 2018 May;101:77-84. doi: 10.1016/j.yhbeh.2017.11.009. Epub 2017 Dec 6.
Triclosan, an antimicrobial agent used in some consumer products, reduces endogenous thyroid hormone concentrations in rodents. Despite ubiquitous triclosan exposure and the importance of thyroid hormones for normal fetal development, few human studies have examined the impact of triclosan exposure on maternal, neonatal, or child thyroid hormones.
In the HOME Study, a prospective cohort from Cincinnati, OH, we measured urinary triclosan concentrations up to three times in pregnant women between 16weeks and delivery, and up to three times in children between age 1-3years. We quantified serum concentrations of thyroid stimulating hormone and total and free thyroxine and triiodothyronine in mothers at 16-weeks gestation (n=202), neonates at delivery (n=274), and children at age 3years (n=153). We estimated covariate-adjusted differences in thyroid hormones with a 10-fold increase in triclosan using linear regression and multiple informants models.
Triclosan was not associated with thyroid hormones during pregnancy. We observed a few associations of triclosan concentrations with thyroid hormone concentrations in neonates at delivery and children at age 3years. Higher gestational triclosan, particularly around the time of delivery, was associated with lower cord serum total thyroxine (β: 0.3μg/dL; 95% CI: -0.6, -0.0). Childhood triclosan, particularly at age 1year, was positively associated with total thyroxine at age 3years (β: 0.7μg/dL; 95% CI: 0.3, 1.2).
Our findings suggest that triclosan exposure may influence some features of neonatal and early child thyroid function. Given the large number of comparisons we made, these findings should be replicated in other cohorts.
三氯生是一种用于某些消费品的抗菌剂，它会降低啮齿动物体内的内源性甲状腺激素浓度。尽管三氯生普遍存在，并且甲状腺激素对正常胎儿发育很重要，但很少有人类研究检查三氯生暴露对产妇、新生儿或儿童甲状腺激素的影响。
在辛辛那提的前瞻性队列 HOME 研究中，我们在孕妇妊娠 16 周到分娩期间测量了多达 3 次的尿液三氯生浓度，在儿童 1-3 岁期间测量了多达 3 次。我们在孕妇妊娠 16 周时（n=202）、新生儿分娩时（n=274）和儿童 3 岁时（n=153）测量了血清促甲状腺激素以及总甲状腺素和游离甲状腺素的浓度。我们使用线性回归和多信息模型估计了三氯生增加 10 倍时甲状腺激素的协变量调整差异。
三氯生与妊娠期间的甲状腺激素无关。我们观察到一些三氯生浓度与新生儿分娩时和儿童 3 岁时甲状腺激素浓度之间的关联。妊娠期间较高的三氯生，尤其是分娩前后，与脐带血清总甲状腺素浓度降低有关（β：0.3μg/dL；95%CI：-0.6，-0.0）。儿童期三氯生，尤其是 1 岁时，与 3 岁时的总甲状腺素呈正相关（β：0.7μg/dL；95%CI：0.3，1.2）。
我们的研究结果表明，三氯生暴露可能会影响新生儿和幼儿甲状腺功能的某些特征。鉴于我们进行了大量比较，这些发现应在其他队列中得到复制。
