Chung Christopher P, Cao Suzanne, Wakabayashi Grace, Han Ernest S
Division of Gynecologic Oncology, Department of Surgery, City of Hope Medical Center, Duarte, California.
Proc (Bayl Univ Med Cent). 2017 Jul;30(3):291-292. doi: 10.1080/08998280.2017.11929618.
Between 1947 and 1971, the synthetic estrogen diethylstilbestrol (DES) was prescribed to pregnant women to prevent spontaneous abortions. Many studies have demonstrated adverse consequences of prenatal DES exposure. This report describes a DES daughter treated for uterine cancer who presented with a foreshortened vagina of 4 cm and stage III pelvic organ prolapse. She underwent successful vaginal native tissue reconstructive surgery with uterosacral colpopexy and anterior and posterior repair to lengthen her vagina and treat her prolapse. She then developed stress incontinence and underwent periurethral bulking 5 months later. She has been followed for 2 years with no recurrence of prolapse or incontinence.
在1947年至1971年期间，合成雌激素己烯雌酚（DES）被开给孕妇以预防自然流产。许多研究已经证明了产前接触DES的不良后果。本报告描述了一名接受子宫癌治疗的DES女儿，她的阴道缩短至4厘米，并有III期盆腔器官脱垂。她接受了成功的阴道自体组织重建手术，包括子宫骶骨阴道固定术和前后修补术，以延长阴道并治疗脱垂。然后她出现了压力性尿失禁，并在5个月后接受了尿道周围填充治疗。她已被随访2年，脱垂或尿失禁均未复发。
