Kaufman R H, Adam E, Binder G L, Gerthoffer E
Am J Obstet Gynecol. 1980 Jun 1;137(3):299-308. doi: 10.1016/0002-9378(80)90913-8.
Hysterosalpingography (HSG) was performed on 267 diethylstilbestrol (DES)-exposed women. One hundred eighty-five (69%) of these women demonstrated an abnormality and 82 women had normal findings. A relationship between abnormal x-ray findings and structural abnormalities of the cervix and vaginal epithelial changes was noted. Ninety-three women on whom roentgenography was performed had a total of 144 pregnancies. The pregnancy outcome in this group of women was significantly worse than that found in a control population of 87 women who had 147 pregnancies. In addition, women with abnormal x-ray films were found to have a poorer pregnancy outcome than the group of women with normal findings. The women with abnormal x-ray films had more ectopic pregnancies, spontaneous abortions, and premature deliveries than women with normal x-ray films although these differences were not statistically significant. Significantly fewer women with abnormal findings than women with normal x-rays were delivered of term infants.
对267名曾接触己烯雌酚（DES）的女性进行了子宫输卵管造影（HSG）检查。其中185名（69%）女性显示异常，82名女性检查结果正常。研究发现X线异常表现与宫颈结构异常及阴道上皮变化之间存在关联。接受X线检查的93名女性共有144次妊娠。这组女性的妊娠结局明显差于87名有147次妊娠的对照人群。此外，X线片异常的女性妊娠结局比检查结果正常的女性更差。X线片异常的女性比X线片正常的女性有更多的异位妊娠、自然流产和早产，尽管这些差异无统计学意义。与X线正常的女性相比，检查结果异常的女性足月分娩的人数明显更少。
