Kang Eun-Ju, Lee Ki-Nam, Choi Won Jin, Kim Young-Dae, Shin Kyung Min, Lim Jae-Kwang, Lee Jongmin
Department of Radiology, College of Medicine, Dong-A University, Busan 49201, Korea.
Department of Cardiology, College of Medicine, Dong-A University, Busan 49201, Korea.
Korean J Radiol. 2017 Jul-Aug;18(4):664-673. doi: 10.3348/kjr.2017.18.4.664. Epub 2017 May 19.
To assess the normal reference values of left ventricle (LV) functional parameters in Korean adults on coronary CT angiography (CCTA) with a 320-detector-row CT scanner, and to analyze sex-related differences and correlations with various clinical characteristics.
This study retrospectively enrolled 172 subjects (107 men and 65 women; age, 58 ± 10.9 years; body surface area [BSA], 1.75 ± 0.2 m) who underwent CCTA without any prior history of cardiac disease. The following parameters were measured by post-processing the CT data: LV volume, LV functional parameters (ejection fraction, stroke volume, cardiac output, etc.), LV myocardial mass, LV inner diameter, and LV myocardial thickness (including septal wall thickness [SWT], posterior wall thickness [PWT], and relative wall thickness [RWT = 2 × PWT / LV inner diameter]). All of the functional or volumetric parameters were normalized using the BSA. The general characteristics and co-morbidities for the enrolled subjects were recorded, and the correlations between these factors and the LV parameters were then evaluated.
The LV myocardial thickness (SWT, 1.08 ± 0.18 cm vs. 0.90 ± 0.17 cm, < 0.001; PWT, 0.91 ± 0.15 cm vs. 0.78 ± 0.10 cm, < 0.001; RWT, 0.38 ± 0.08 cm vs. 0.33 ± 0.05 cm, < 0.001), LV volume (LV end-diastolic volume, 112.9 ± 26.1 mL vs. 98.2 ± 21.0 mL, < 0.001; LV end-systolic volume, 41.7 ± 14.7 mL vs. 33.7 ± 12.2 mL, = 0.001) and mass (145.0 ± 29.1 g vs. 107.9 ± 20.0 g, < 0.001) were significantly greater in men than in women. However, these differences were not significant after normalization using BSA, except for the LV mass (LV mass index, 79.6 ± 14.0 g/m vs. 66.2 ± 11.0 g/m, < 0.001). The cardiac output and ejection fraction were not significantly different between the men and women (cardiac output, 4.3 ± 1.0 L/min vs. 4.2 ± 0.9 L/min, = 0.452; ejection fraction, 63.4 ± 7.7% vs. 66.4 ± 7.6%, = 0.079). Most of the LV parameters were positively correlated with BSA, body weight, and total Agatston score.
This study provides sex-related reference values and percentiles for LV on cardiac CT and should assist in interpreting results.
使用320排CT扫描仪评估韩国成年人冠状动脉CT血管造影（CCTA）中左心室（LV）功能参数的正常参考值，并分析性别差异以及与各种临床特征的相关性。
本研究回顾性纳入了172名受试者（107名男性和65名女性；年龄58±10.9岁；体表面积[BSA]1.75±0.2平方米），这些受试者均接受了CCTA检查且既往无任何心脏病史。通过对CT数据进行后处理测量以下参数：左心室容积、左心室功能参数（射血分数、每搏输出量、心输出量等）、左心室心肌质量、左心室内径以及左心室心肌厚度（包括室间隔厚度[SWT]、后壁厚度[PWT]和相对壁厚度[RWT = 2×PWT / 左心室内径]）。所有功能或容积参数均使用体表面积进行标准化。记录纳入受试者的一般特征和合并症，然后评估这些因素与左心室参数之间的相关性。
男性的左心室心肌厚度（室间隔厚度，1.08±0.18厘米对0.90±0.17厘米，<0.001；后壁厚度，0.91±0.15厘米对0.78±0.10厘米，<0.001；相对壁厚度，0.38±0.08厘米对0.33±0.05厘米，<0.001）、左心室容积（左心室舒张末期容积，112.9±26.1毫升对98.2±21.0毫升，<0.001；左心室收缩末期容积，41.7±14.7毫升对33.7±12.2毫升，=0.001）和质量（145.0±29.1克对107.9±20.0克，<0.001）均显著大于女性。然而，除左心室质量外（左心室质量指数，79.6±14.0克/平方米对66.2±11.0克/平方米，<0.001），使用体表面积进行标准化后这些差异并不显著。男性和女性的心输出量和射血分数无显著差异（心输出量，4.3±1.0升/分钟对4.2±0.9升/分钟，=0.452；射血分数，63.4±7.7%对66.4±7.6%，=
