Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Clin Imaging. 2019 Jul-Aug;56:81-87. doi: 10.1016/j.clinimag.2019.04.002. Epub 2019 Apr 12.
To use adenosine-induced stress CT myocardial perfusion imaging (CT-MPI) to determine normal reference values for left ventricle (LV) wall thickness (WT) and motion parameters.
This study included 106 Korean subjects (52 men and 54 women) who underwent CT-MPI due to chest pain, but were not found to have any detectable mild or severe coronary artery disease or myocardial perfusion defect. The following quantitative parameters were assessed on the CT-MPI according to a 17-segment model: LV myocardial thickness at end-systolic (WT) and end-diastolic (WT) phases, systolic wall thickening (SWT), and wall motion (WM). The associations of the measured parameters with the subjects' demographic characteristics and comorbidities were also analyzed.
Septal wall (7.2 mm) and basal-level (7.7 mm) LV myocardium demonstrated significantly higher WT (p < 0.001). SWT was highest in lateral (77.8%, p < 0.014) and apical (78.9%, p = 0.009) myocardium, while lateral (7.7 mm) and basal (6.7 mm) myocardium exhibited the greatest WM (p < 0.001). WT was significantly higher in men and younger (<60 years) subjects (all, p < 0.001). Hypertensive individuals presented with significantly higher SWT (79.9%, p = 0.024). LV WT exhibited statistically significant correlations (all positive, except for age) with age, height, weight, body surface area, body mass index, and systolic blood pressure (all, p < 0.010).
The present study provides CT-MPI reference values for LV myocardial WT, SWT, and WM measured on an adult Korean population. Knowledge of such normal reference measurements would be beneficial for the efficient interpretation of CT-MPI examinations in populations of Asian ethnicity.
利用腺苷诱导的应激 CT 心肌灌注成像（CT-MPI）确定左心室（LV）壁厚度（WT）和运动参数的正常参考值。
本研究纳入 106 例因胸痛行 CT-MPI 检查但未发现任何可检测到的轻度或重度冠状动脉疾病或心肌灌注缺陷的韩国受试者（52 名男性和 54 名女性）。根据 17 节段模型评估 CT-MPI 的以下定量参数：LV 心肌在收缩末期（WT）和舒张末期（WT）的厚度、收缩期壁增厚（SWT）和壁运动（WM）。还分析了所测量参数与受试者的人口统计学特征和合并症的相关性。
室间隔壁（7.2mm）和基底段（7.7mm）LV 心肌的 WT 明显更高（p<0.001）。SWT 在外侧（77.8%，p<0.014）和心尖（78.9%，p=0.009）心肌最高，而外侧（7.7mm）和基底（6.7mm）心肌的 WM 最大（p<0.001）。WT 在男性和较年轻（<60 岁）的受试者中明显更高（均，p<0.001）。高血压患者的 SWT 明显更高（79.9%，p=0.024）。LV WT 与年龄、身高、体重、体表面积、体重指数和收缩压均呈显著正相关（均，p<0.010）。
本研究提供了基于成年韩国人群的 CT-MPI 左心室心肌 WT、SWT 和 WM 的参考值。了解这些正常参考值对于解释亚洲人群的 CT-MPI 检查结果将非常有益。
