Fluorescein sodium-guided surgery of parotid gland tumors as a technical advance.
作者信息
Haubner Frank, Gassner Holger G, Brawanski Alexander, Schebesch Karl-Michael
机构信息
Department of Otorhinolaryngology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.
出版信息
BMC Ear Nose Throat Disord. 2017 Jun 28;17:6. doi: 10.1186/s12901-017-0039-7. eCollection 2017.
BACKGROUND
Complete tumor removal and preservation of the facial nerve are essential in parotid gland surgery. A technical adjunct that potentially enhances the contrast between the facial nerve and the adherent tumor tissue and allows to identify residual tumor tissue could be Fluorescein Sodium.
METHODS
Retrospective chart analysis on 7 patients with benign parotid gland lesions that were operated using Fluorescein Sodium intravenously and the application of the YELLOW 560 nm filter of the operating microscope. Safety and feasibility were evaluated.
RESULTS
All tumors showed fluorescence and the rating ´contrast-enhancing´ was assigned in all cases. In 2 patients, satellite nodules were identified and resected meaning that the fluorescence staining of the tumor margins was significantly better than under white light.
CONCLUSION
The use of Fluorescein Sodium in parotidectomy is promising. In two cases residual tumor was detected that would have been left behind under white light. Further research in parotid gland surgery and other head and neck tumor procedures is warranted.
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