Howden C W, Burget D W, Silletti C, Hunt R H
Hepatogastroenterology. 1985 Oct;32(5):240-2.
The gastric antisecretory effects of two dose levels of pirenzepine given at night were investigated in a group of healthy male volunteers. Compared with placebo, three days of treatment with pirenzepine 100 mg nocte or 150 mg nocte inhibited mean nocturnal intragastric acidity by 54% and 53%, respectively (p less than 0.01). The volume of gastric juice secreted was reduced by 47% and 52% (p less than 0.005), by 100 mg and 150 mg nocte, respectively. Each dose suppressed mean gastric acid output by 67% (p less than 0.001). Pepsin output was not significantly altered. There were no differences in effect between the two dose levels studied, but side-effects such as dry mouth were only seen with the higher dose. Pirenzepine 100 mg is the optimum dose which can conveniently be given at night. This will limit side-effects, and may be a useful treatment for patients with duodenal ulcer.
在一组健康男性志愿者中研究了夜间给予两种剂量的哌仑西平的胃抗分泌作用。与安慰剂相比，每晚服用100毫克或150毫克哌仑西平三天，分别使夜间胃内平均酸度降低54%和53%（p<0.01）。每晚服用100毫克和150毫克哌仑西平，胃液分泌量分别减少47%和52%（p<0.005）。每种剂量均使平均胃酸分泌量抑制67%（p<0.001）。胃蛋白酶分泌量无明显改变。所研究的两种剂量水平之间在效果上无差异，但副作用如口干仅在较高剂量时出现。100毫克哌仑西平是可方便地在夜间给予的最佳剂量。这将限制副作用，并且可能是十二指肠溃疡患者的一种有效治疗方法。
