Gabryelewicz A, Laszewicz W, Sarosiek J
Scand J Gastroenterol Suppl. 1980;66:79-85.
The effects of pirenzepine and the H2-blocker ranitidine on pepsin secretion were studied in patients with duodenal ulcer. Pirenzepine and ranitidine in doses of 0.3 mg/kg-h inhibited pentagastrin-stimulated pepsin secretion by 63% and 82% respectively. The highest doses used of pirenzepine (0.6 mg/kg-h) and ranitidine (0.9 mg/kg-h) inhibited pepsin secretion by 69 and 93% respectively, whereas acid output was inhibited by 57 and 98%. Pirenzepine inhibited pepsin output more than hydrochloric acid output. However, pepsin output was less inhibited than hydrochloric acid output by ranitidine. These results suggest that pirenzepine might be especially useful in the treatment of those patients with peptic ulcer who have high proteolytic activity of their gastric juice.
在十二指肠溃疡患者中研究了哌仑西平和H2受体阻滞剂雷尼替丁对胃蛋白酶分泌的影响。剂量为0.3mg/kg-h的哌仑西平和雷尼替丁分别使五肽胃泌素刺激的胃蛋白酶分泌抑制63%和82%。所用哌仑西平的最高剂量（0.6mg/kg-h）和雷尼替丁的最高剂量（0.9mg/kg-h）分别使胃蛋白酶分泌抑制69%和93%，而胃酸分泌分别抑制57%和98%。哌仑西平对胃蛋白酶分泌的抑制作用比对盐酸分泌的抑制作用更强。然而，雷尼替丁对胃蛋白酶分泌的抑制作用比对盐酸分泌的抑制作用弱。这些结果表明，哌仑西平可能对那些胃液蛋白水解活性高的消化性溃疡患者特别有用。
