用于组织再生的基质细胞衍生因子1α的递送
Delivery of stromal cell-derived factor 1α for tissue regeneration.
作者信息
Zhao Wen, Jin Kaixiang, Li Jiaojiao, Qiu Xuefeng, Li Song
机构信息
Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072 China.
Department of Bioengineering and Department of Medicine, University of California, Los Angeles, CA 90095 USA.
出版信息
J Biol Eng. 2017 Jun 29;11:22. doi: 10.1186/s13036-017-0058-3. eCollection 2017.
Abstract
tissue regeneration approach aims to exploit the body's own biological resources and reparative capability and recruit host cells by utilizing cell-instructive biomaterials. In order to immobilize and release bioactive factors in biomaterials, it is important to engineer the load effectiveness, release kinetics and cell recruiting capabilities of bioactive molecules by using suitable bonding strategies. Stromal cell-derived factor 1α (SDF-1α) is one of the most potent chemokines for stem cell recruitment, and SDF-1α-loaded scaffolds have been used for the regeneration of many types of tissues. This review summarizes the strategies to incorporate SDF-1α into scaffolds, including direct loading or adsorption, polyion complexes, specific heparin-mediated interaction and particulate system, which may be applied to the immobilization of other chemokines or growth factors. In addition, we discuss the application of these strategies in the regeneration of tissues such as blood vessel, myocardium, cartilage and bone.
摘要
组织再生方法旨在利用人体自身的生物资源和修复能力，并通过使用具有细胞指导作用的生物材料来募集宿主细胞。为了在生物材料中固定和释放生物活性因子，利用合适的结合策略来设计生物活性分子的负载效率、释放动力学和细胞募集能力非常重要。基质细胞衍生因子1α（SDF-1α）是用于干细胞募集的最有效的趋化因子之一，负载SDF-1α的支架已被用于多种组织的再生。本文综述了将SDF-1α整合到支架中的策略，包括直接负载或吸附、聚离子复合物、特定的肝素介导的相互作用和颗粒系统，这些策略也可应用于其他趋化因子或生长因子的固定。此外，我们还讨论了这些策略在血管、心肌、软骨和骨等组织再生中的应用。
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