Cai Guiyang, Hou Zhipeng, Sun Wei, Li Peng, Zhang Jinzhe, Yang Liqun, Chen Jing
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang, China.
Front Bioeng Biotechnol. 2022 Jun 20;10:894252. doi: 10.3389/fbioe.2022.894252. eCollection 2022.
Endometrial injury caused by intrauterine surgery often leads to pathophysiological changes in the intrauterine environment, resulting in infertility in women of childbearing age. However, clinical treatment strategies, especially for moderate to severe injuries, often fail to provide satisfactory therapeutic effects and pregnancy outcomes. With the development of reproductive medicine and materials engineering, researchers have developed bioactive hydrogel materials, which can be used as a physical anti-adhesion barrier alone or as functional delivery systems for intrauterine injury treatment by loading stem cells or various active substances. Studies have demonstrated that the biomaterial-based hydrogel delivery system can provide sufficient mechanical support and improve the intrauterine microenvironment, enhance the delivery efficiency of therapeutic agents, prolong intrauterine retention time, and perform efficiently targeted repair compared with ordinary drug therapy or stem cell therapy. It shows the promising application prospects of the hydrogel delivery system in reproductive medicine. Herein, we review the recent advances in endometrial repair methods, focusing on the current application status of biomaterial-based hydrogel delivery systems in intrauterine injury repair, including preparation principles, therapeutic efficacy, repair mechanisms, and current limitations and development perspectives.
宫内手术引起的子宫内膜损伤常导致子宫内环境的病理生理变化，从而导致育龄期女性不孕。然而，临床治疗策略，尤其是针对中重度损伤的治疗策略，往往无法提供令人满意的治疗效果和妊娠结局。随着生殖医学和材料工程的发展，研究人员开发了生物活性水凝胶材料，其可单独用作物理防粘连屏障，或通过负载干细胞或各种活性物质用作子宫内损伤治疗的功能性递送系统。研究表明，与普通药物治疗或干细胞治疗相比，基于生物材料的水凝胶递送系统可提供足够的机械支撑，改善子宫内微环境，提高治疗剂的递送效率，延长子宫内滞留时间，并进行高效靶向修复。它显示了水凝胶递送系统在生殖医学中的广阔应用前景。在此，我们综述了子宫内膜修复方法的最新进展，重点关注基于生物材料的水凝胶递送系统在子宫内损伤修复中的应用现状，包括制备原理、治疗效果、修复机制以及当前的局限性和发展前景。
