Woolbright Benjamin L, Jaeschke Hartmut
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.
J Clin Transl Res. 2017 Feb;3(Suppl 1):170-188. doi: 10.18053/jctres.03.2017S1.003. Epub 2017 Feb 12.
The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; however, a great deal of controversy and many questions about the nature of sterile inflammation still exist.
The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate.
Inflammation is one of the most critical factors for managing in-patient liver disease in a number of scenarios. More information is needed for both scientists and clinicians to develop rational treatments.
肝脏在固有免疫中具有多种功能。当炎症未得到控制时，这些功能会使肝脏易发生固有免疫介导的肝损伤。在过去25年里，在多种模型中关于无菌性炎症性肝损伤已取得显著进展；然而，关于无菌性炎症的本质仍存在大量争议和诸多问题。
本文的目的是通过采用构成炎症性损伤的基本方法以及研究当前肝损伤和炎症模型来综述无菌性炎症性肝损伤。如有适当情况，此信息将与人类患者状况相关联。
在多种情况下，炎症是管理住院肝病患者时最关键的因素之一。科学家和临床医生都需要更多信息来制定合理的治疗方案。
