载超氧化物歧化酶的多孔聚合物泡囊作为高效抗氧化剂治疗神经病理性疼痛。
Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain.
机构信息
Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
Department of Systems Pharmacology and Translational Therapeutics, Center for Translational Targeted Therapeutics and Nanomedicine of the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
出版信息
Adv Healthc Mater. 2017 Sep;6(17). doi: 10.1002/adhm.201700500. Epub 2017 Jul 3.
Abstract
A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD-encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone.
摘要
一种高效抗氧化剂是通过将超氧化物歧化酶（SOD）封装在多孔聚合物泡囊的水相内部来开发的。多孔聚合物泡囊提供了一个可渗透的膜，允许游离的超氧自由基进入水相内部并与封装的抗氧化酶 SOD 相互作用。在大鼠体内研究中，与单独使用游离抗氧化酶治疗相比，给予 SOD 封装的多孔聚合物泡囊可更有效地预防神经根压迫后的神经病理性疼痛。
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