Hadgraft J, Walters K A, Wotton P K
J Pharm Pharmacol. 1985 Oct;37(10):725-7. doi: 10.1111/j.2042-7158.1985.tb04951.x.
The ability of Azone (1-dodecylazacylcoheptan-2-one), a recently developed penetration enhancer, to facilitate the transport of sodium salicylate across an artificial lipid membrane has been investigated using the rotating diffusion cell, a well defined model for percutaneous absorption. Azone was found to be capable of enhancing the transport of the salicylate anion across an isopropyl myristate membrane, by using a pH gradient as the chemical driving force. The results indicate that Azone may be capable of forming ion pairs with anionic drugs.
最近开发的渗透促进剂氮酮（1-十二烷基氮杂环庚烷-2-酮）促进水杨酸钠透过人工脂质膜转运的能力，已使用旋转扩散池进行了研究，旋转扩散池是一种用于经皮吸收的明确模型。通过使用pH梯度作为化学驱动力，发现氮酮能够增强水杨酸根阴离子透过肉豆蔻酸异丙酯膜的转运。结果表明，氮酮可能能够与阴离子药物形成离子对。
