一种用于测定药物中水杨酸和乙酰水杨酸的新型水杨酸盐离子敏感场效应晶体管。

A new salicylate ISFET for the determination of salicylic and acetylsalicylic acid in drugs.

作者信息

Su Y, Tomassetti M, Sammartino M P, Crescentini G, Campanella L

机构信息

Institute of Soil Science, Academia Sinica, Nanjing, China.

出版信息

J Pharm Biomed Anal. 1995 Apr;13(4-5):449-57. doi: 10.1016/0731-7085(95)01320-k.

DOI:10.1016/0731-7085(95)01320-k

PMID:9696555

Abstract

A salicylate ISFET for the analysis of salicylic and acetylsalicylic acid in drugs is described. It is based on a salicylate ion selective membrane coated on the surface of the Si3N4 gate of the FET. The sensitive membrane consists of tetra-dodecylammonium salicylate, polyvinyl chloride and a proper plasticizer. The linearity range of the sensor is 5 x 10(-5)-1.5 x 10(-2) M for the salicylic acid, and 7 x 10(-5)-1.5 x 10(-2) M for the acetylsalicylic acid, respectively. The detection limit for the two compounds is 5 x 10(-5) M while the response time is < or = 20 s. The effect of pH and different interfering ions was also studied. The sensor was used to analyse the content of acetylsalicylic and salicylic acid in some drugs, and the accuracy of the method was evaluated through recovery tests. The results obtained with this method are well correlated either with those obtained with a classical ISE employing the same sensitive membrane or with the classical volumetric method.

摘要

描述了一种用于分析药物中水杨酸和乙酰水杨酸的水杨酸离子敏感场效应晶体管（ISFET）。它基于涂覆在FET的Si3N4栅极表面的水杨酸离子选择性膜。敏感膜由水杨酸十四烷基铵、聚氯乙烯和适当的增塑剂组成。该传感器对水杨酸的线性范围为5×10^(-5)-1.5×10^(-2) M，对乙酰水杨酸的线性范围为7×10^(-5)-1.5×10^(-2) M。两种化合物的检测限为5×10^(-5) M，响应时间≤20 s。还研究了pH值和不同干扰离子的影响。该传感器用于分析某些药物中乙酰水杨酸和水杨酸的含量，并通过回收率试验评估了该方法的准确性。用该方法获得的结果与采用相同敏感膜的经典离子选择性电极（ISE）获得的结果或经典容量法获得的结果具有良好的相关性。