苯扎贝特对大鼠实验性肾病综合征高脂血症的影响。
The effect of bezafibrate on hyperlipidaemia in experimental nephrotic syndrome in rats.
作者信息
Williams A J, Baker F E, Walls J
出版信息
J Pharm Pharmacol. 1985 Oct;37(10):741-3. doi: 10.1111/j.2042-7158.1985.tb04957.x.
Abstract
The effects of bezafibrate on hyperlipidaemia in experimental nephrotic syndrome in rats has been investigated. The treated group received bezafibrate 10 mg kg-1 p.o. daily. No significant differences in total serum cholesterol occurred, but a significant reduction in serum triglyceride (P less than 0.005) and elevation in HDL cholesterol (P less than 0.005) occurred. These findings may have implications for therapeutic intervention in severe hyperlipidaemia of the nephrotic syndrome in man.
摘要
已对苯扎贝特对大鼠实验性肾病综合征高脂血症的影响进行了研究。治疗组每日口服苯扎贝特10mg/kg。血清总胆固醇无显著差异，但血清甘油三酯显著降低（P<0.005），高密度脂蛋白胆固醇升高（P<0.005）。这些发现可能对人类肾病综合征严重高脂血症的治疗干预具有启示意义。
相似文献
1
The effect of bezafibrate on hyperlipidaemia in experimental nephrotic syndrome in rats.苯扎贝特对大鼠实验性肾病综合征高脂血症的影响。
J Pharm Pharmacol. 1985 Oct;37(10):741-3. doi: 10.1111/j.2042-7158.1985.tb04957.x.
2
Dual bezafibrate-simvastatin therapy for combined hyperlipidaemia.
J Clin Pharm Ther. 1994 Dec;19(6):387-9. doi: 10.1111/j.1365-2710.1994.tb00698.x.
3
Hypocholesterolemic effect of spirulina in patients with hyperlipidemic nephrotic syndrome.螺旋藻对高脂血症性肾病综合征患者的降胆固醇作用。
J Med Food. 2002 Summer;5(2):91-6. doi: 10.1089/109662002760178177.
4
Toxicity of lovastatin in rats with experimentally induced nephrotic syndrome.
Nephron. 1990;56(4):399-404. doi: 10.1159/000186183.
5
Effect of vegetarian soy diet on hyperlipidaemia in nephrotic syndrome.素食大豆饮食对肾病综合征高脂血症的影响。
Lancet. 1992 May 9;339(8802):1131-4. doi: 10.1016/0140-6736(92)90731-h.
6
Effect of probucol on hyperlipidemia in patients with nephrotic syndrome.普罗布考对肾病综合征患者高脂血症的影响。
Nephron. 1987;47(4):280-3. doi: 10.1159/000184524.
7
Effect of lovastatin and bezafibrate on cyclosporine-induced hyperlipidemia in rabbits.洛伐他汀和苯扎贝特对环孢素诱导的兔高脂血症的影响。
Transplant Proc. 1995 Apr;27(2):1857-61.
8
Improvement of hyperlipidaemia by bezafibrate treatment in RDT patients.苯扎贝特治疗对RDT患者高脂血症的改善作用。
Proc Eur Dial Transplant Assoc. 1981;18:169-75.
9
Long-term effects of bezafibrate on in vivo VLDL-triglyceride production in the rat.苯扎贝特对大鼠体内极低密度脂蛋白甘油三酯生成的长期影响。
Diabetes Res Clin Pract. 1990 May-Jun;9(2):163-8. doi: 10.1016/0168-8227(90)90108-6.
10
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.酰基辅酶A：胆固醇酰基转移酶抑制可改善肾病综合征中的蛋白尿、高脂血症、卵磷脂胆固醇酰基转移酶、SRB-1及低密度脂蛋白受体缺陷。
Circulation. 2004 Jul 27;110(4):419-25. doi: 10.1161/01.CIR.0000136023.70841.0F. Epub 2004 Jul 19.
Zotero 插件