de Mello-Sampayo Cristina, Paterna Angela, Polizzi Ambra, Duarte Diana, Batista Irineu, Pinto Rui, Gonçalves Patrícia, Raymundo Anabela, Batista Ana P, Gouveia Luísa, Silva-Lima Beatriz, Bandarra Narcisa M
Department of Pharmacological Sciences, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Lisbon 1649-003, Portugal.
Division of Aquaculture and Upgrading, Portuguese Institute for the Sea and Atmosphere (IPMA, IP), Rua Alfredo Magalhães Ramalho, Lisbon 1495-006, Portugal.
Molecules. 2017 Jul 1;22(7):1097. doi: 10.3390/molecules22071097.
is a marine microalgae for which supposed health promoting effects have been claimed based on its phytochemical composition. The potential use of its biomass as health ingredient, including detox-shakes, and the lack of bioavailability studies were the main concerns. In order to evaluate the microalgae-biomass assimilation and its health-benefits, single-dose (CD1-mice) studies were followed by 66-days repeated-dose study in Wistar rats with the highest tested single-dose of microalgae equivalent to 101 mg/kg eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA). Microalgae-supplementation modulated EPA and docosapentaenoic acid enrichment at arachidonic acid content expenditure in erythrocytes and liver, while increasing EPA content of heart and adipose tissues of rats. Those fatty acid (FA) changes confirmed the -biomass FA assimilation. The principal component analyses discriminated brain from other tissues, which formed two other groups (erythrocytes, liver, and heart separated from kidney and adipose tissues), pointing to a distinct signature of FA deposition for the brain and for the other organs. The improved serum lipid profile, omega-3 index and erythrocyte plasticity support the cardiovascular benefits of . These results bolster the potential of -biomass to become a "heart-healthy" food supplement providing a safe and renewable source of bioavailable omega-3 FA.
是一种海洋微藻，因其植物化学成分据称具有促进健康的作用。人们主要关注的是其生物质作为健康成分（包括排毒奶昔）的潜在用途，以及缺乏生物利用度研究。为了评估微藻生物质的同化作用及其对健康的益处，先对CD1小鼠进行单剂量研究，随后对Wistar大鼠进行为期66天的重复剂量研究，所测试的微藻最高单剂量相当于101毫克/千克二十碳五烯酸 + 二十二碳六烯酸（EPA+DHA）。补充微藻可调节红细胞和肝脏中花生四烯酸含量消耗时EPA和二十二碳五烯酸的富集，同时增加大鼠心脏和脂肪组织中的EPA含量。这些脂肪酸（FA）变化证实了生物质FA的同化作用。主成分分析将大脑与其他组织区分开来，其他组织形成另外两组（红细胞、肝脏和心脏与肾脏和脂肪组织分开），表明大脑和其他器官的FA沉积具有明显特征。改善的血脂谱、ω-3指数和红细胞可塑性支持了其对心血管的益处。这些结果支持了微藻生物质成为“心脏健康”食品补充剂的潜力，提供了一种安全且可再生的生物可利用ω-3 FA来源。
