非索非那定在钯过敏小鼠模型中抑制迟发型超敏反应。

Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy.

作者信息

Matsubara Ryota, Kumagai Kenichi, Shigematsu Hiroaki, Kitaura Kazutaka, Nakasone Yasunari, Suzuki Satsuki, Hamada Yoshiki, Suzuki Ryuji

机构信息

Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-3-1 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.

Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.

出版信息

Int J Mol Sci. 2017 Jun 25;18(7):1357. doi: 10.3390/ijms18071357.

DOI:10.3390/ijms18071357

PMID:28672829

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5535850/

Abstract

Palladium is frequently used in dental materials, and sometimes causes metal allergy. It has been suggested that the immune response by palladium-specific T cells may be responsible for the pathogenesis of delayed-type hypersensitivity in study of palladium allergic model mice. In the clinical setting, glucocorticoids and antihistamine drugs are commonly used for treatment of contact dermatitis. However, the precise mechanism of immune suppression in palladium allergy remains unknown. We investigated inhibition of the immune response in palladium allergic mice by administration of prednisolone as a glucocorticoid and fexofenadine hydrochloride as an antihistamine. Compared with glucocorticoids, fexofenadine hydrochloride significantly suppressed the number of T cells by interfering with the development of antigen-presenting cells from the sensitization phase. Our results suggest that antihistamine has a beneficial effect on the treatment of palladium allergy compared to glucocorticoids.

摘要

钯常用于牙科材料，有时会引发金属过敏。在钯过敏模型小鼠的研究中，有人提出钯特异性T细胞的免疫反应可能是迟发型超敏反应发病机制的原因。在临床环境中，糖皮质激素和抗组胺药物常用于治疗接触性皮炎。然而，钯过敏中免疫抑制的确切机制仍不清楚。我们研究了通过给予泼尼松龙（一种糖皮质激素）和盐酸非索非那定（一种抗组胺药）来抑制钯过敏小鼠的免疫反应。与糖皮质激素相比，盐酸非索非那定通过在致敏阶段干扰抗原呈递细胞的发育，显著抑制了T细胞的数量。我们的结果表明，与糖皮质激素相比，抗组胺药对钯过敏的治疗具有有益作用。