Xiao Yizhi, Luo Hui, Liu Shiqing, Duan Liping, You Yunhui, Zhao Hongjun, Zuo Xiaoxia
Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Exp Ther Med. 2017 Jul;14(1):349-354. doi: 10.3892/etm.2017.4447. Epub 2017 May 11.
Idiopathic inflammatory myopathy (IIM) comprises a group of rare systemic diseases characterized by progressive weakness of the symmetrical proximal limb muscles, elevated muscle enzymes, inflammation or necrosis on muscle biopsy. IIM may impair the function of multiple organs, particularly the heart. However, it rarely manifests as acute myocardial infarction (AMI) at initial presentation. The present study described the case of a 39-year-old woman with AMI, whose muscle biopsy on the left arm conformed to polymyositis. Coronary arteriography showed irregularities in the left descending and right coronary artery (25% diameter reduction in middle segment). It was concluded that AMI was the chief manifestation of IIM at initial presentation. Furthermore, to the best of our knowledge, the present study was the first to provide a systematic literature review to assess AMI in IIM patients and discuss the possible causes of AMI.
特发性炎性肌病（IIM）是一组罕见的全身性疾病，其特征为对称性近端肢体肌肉进行性无力、肌肉酶升高、肌肉活检显示炎症或坏死。IIM可能损害多个器官的功能，尤其是心脏。然而，在初次就诊时它很少表现为急性心肌梗死（AMI）。本研究描述了一名39岁患有AMI的女性病例，其左臂肌肉活检符合多发性肌炎。冠状动脉造影显示左前降支和右冠状动脉不规则（中段直径减少25%）。得出的结论是，AMI是IIM初次就诊时的主要表现。此外，据我们所知，本研究首次提供了一项系统的文献综述，以评估IIM患者中的AMI并讨论AMI的可能原因。
