Mahjour Marjan, Khoushabi Arash, Feyzabadi Zohre
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences, Mashhad, Iran.
Med Hypotheses. 2017 Jul;104:1-3. doi: 10.1016/j.mehy.2017.05.006. Epub 2017 May 8.
Melasma is a facial hyperpigmentation in the upper lips, cheeks, forehead and chin. It is mostly seen in women. Melasma treatments include topical methods that are not only costly, but also temporary. Melasma recurs shortly after cessation of the treatment. Considering the relationship between melasma and elevated estrogen levels in patients with oligomenorrhea, systemic anti-estrogen therapies are not used for melasma. In this study, by searching in the scientific databases such as Scopus, Pubmed and the authentic books of traditional medicine such as the Canon of medicine, melasma treatment was evaluated based on oligomenorrhea systemic therapy. The results of this study showed that if melasma is due to oligomenorrhea, the use of systemic anti-estrogenic therapies can improve melasma by reducing of Melanogenesis due to decreasing α msh (alpha-Melanocyte-stimulating hormone) in addition to oligomenorrhea improvement. However, because of the extreme attention to the advertising cosmetic creams, attention to systemic therapies has been faded. According to traditional medicine, the use of menstruation-inducing systemic therapies can be more effective in melasma than topical treatments because of removing of the disease agent. Given the important role of oligomenorrhea in creating of melasma, it is suggested conducting more studies on the effect of systemic therapy of oligomenorrhea on melasma treatment. If proven, to be considered as the treatment strategies for this disease.
黄褐斑是一种出现在上唇、脸颊、额头和下巴的面部色素沉着过度。多见于女性。黄褐斑的治疗方法包括局部治疗，这些方法不仅成本高，而且只是暂时的。治疗停止后不久黄褐斑就会复发。考虑到黄褐斑与月经过少患者雌激素水平升高之间的关系，系统性抗雌激素疗法不用于治疗黄褐斑。在本研究中，通过检索Scopus、Pubmed等科学数据库以及《医学大典》等传统医学权威书籍，基于月经过少的系统性治疗对黄褐斑治疗进行了评估。本研究结果表明，如果黄褐斑是由月经过少引起的，那么使用系统性抗雌激素疗法除了改善月经过少外，还可通过减少α -促黑素（α -黑素细胞刺激激素）从而减少黑素生成来改善黄褐斑。然而，由于过度关注广告宣传的美容面霜，对系统性疗法的关注已经减少。根据传统医学，使用诱导月经的系统性疗法治疗黄褐斑可能比局部治疗更有效，因为它能消除病因。鉴于月经过少在黄褐斑形成中的重要作用，建议对月经过少的系统性治疗对黄褐斑治疗的效果进行更多研究。如果得到证实，可将其视为该病的治疗策略。
