Department of Neuroscience, Oberlin College, 119 Woodland St, Oberlin, OH 44074, USA.
Department of Neuroscience, Oberlin College, 119 Woodland St, Oberlin, OH 44074, USA.
Front Neuroendocrinol. 2017 Oct;47:19-33. doi: 10.1016/j.yfrne.2017.06.003. Epub 2017 Jun 30.
Schizophrenia is a complex neuropsychiatric illness with marked sex differences. Women have later onset and lesser symptoms, which has led to the hypothesis that estrogens are protective in schizophrenia. Cognitive dysfunction is a hallmark of the disease and the symptom most correlated with functional outcome. Here we describe a number of mechanisms by which estrogens may be therapeutic in schizophrenia, with a focus on cognitive symptoms. We review the relationship between estrogens and brain derived neurotrophic factor, neuroinflammation, NMDA receptors, GABA receptors, and luteinizing hormone. Exploring these pathways may enable novel treatments for schizophrenia and a greater understanding of this devastating disease.
精神分裂症是一种复杂的神经精神疾病，具有明显的性别差异。女性发病较晚，症状较轻，这导致了雌激素对精神分裂症具有保护作用的假说。认知功能障碍是该疾病的标志，也是与功能结果最相关的症状。在这里，我们描述了雌激素在精神分裂症中可能具有治疗作用的一些机制，重点是认知症状。我们回顾了雌激素与脑源性神经营养因子、神经炎症、NMDA 受体、GABA 受体和促黄体激素之间的关系。探索这些途径可能为精神分裂症提供新的治疗方法，并更深入地了解这种毁灭性疾病。
