慢性肝炎中的转铁蛋白异构体

The transferrin isoforms in chronic hepatitis.

作者信息

Gruszewska Ewa, Wrona Alicja, Gudowska Monika, Panasiuk Anatol, Cylwik Bogdan, Lipartowska-Klimuk Karina, Flisiak Robert, Chrostek Lech

机构信息

Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A Street, 15-269 Bialystok, Poland.

出版信息

Clin Biochem. 2017 Dec;50(18):1131-1135. doi: 10.1016/j.clinbiochem.2017.06.013. Epub 2017 Jun 30.

DOI:10.1016/j.clinbiochem.2017.06.013

PMID:28673788

Abstract

BACKGROUND

The aim of this study was to evaluate the effect of chronic hepatitis on the serum profile of transferrin isoforms.

METHODS

Tested group consist of 160 patients with chronic hepatitis. The samples were analyzed by capillary electrophoresis on MINICAP electrophoretic system (Sebia, France).

RESULTS

In patients with chronic hepatitis tetrasialotransferrin level was increased (P=0.002) and pentasialotransferrin decreased (P=0.009). Moreover, statistical analysis revealed that trisialotransferrin level was different according to the grade of portal/periportal activity (P=0.009), the grade of lobular activity (P=0.004) and the stage of fibrosis (P=0.022). There were no differences in tetrasialotransferrin and pentasialotransferrin according to the advancement of hepatitis activity and the stage of fibrosis (P>0.05 for all comparisons).

CONCLUSIONS

We conclude that chronic hepatitis affect the serum profile of transferrin isoforms, but only trisialotransferrin level could be useful in determining progression of chronic hepatitis and the stage of fibrosis.

摘要

背景

本研究旨在评估慢性肝炎对转铁蛋白异构体血清谱的影响。

方法

测试组由160例慢性肝炎患者组成。样本在MINICAP电泳系统（法国赛比公司）上通过毛细管电泳进行分析。

结果

慢性肝炎患者中四唾液酸转铁蛋白水平升高（P = 0.002），五唾液酸转铁蛋白水平降低（P = 0.009）。此外，统计分析显示，三唾液酸转铁蛋白水平根据门静脉/门静脉周围活动分级（P = 0.009）、小叶活动分级（P = 0.004）和纤维化阶段（P = 0.022）而有所不同。根据肝炎活动进展和纤维化阶段，四唾液酸转铁蛋白和五唾液酸转铁蛋白没有差异（所有比较P>0.05）。