Mucha Agnieszka, Zaczek Malgorzata, Kralisz Michal, Gruszewska Ewa, Cylwik Bogdan, Panasiuk Anatol, Chrostek Lech
Department of Laboratory Diagnostics, University Clinical Hospital in Bialystok, 15-535 Bialystok, Poland.
Department of Gastroenterology, Hepatology and Internal Diseases with the Center of Diagnostics and Endoscopic Treatment, Provincial Welded Hospital in Bialystok, 15-278 Bialystok, Poland.
J Clin Med. 2022 Mar 16;11(6):1638. doi: 10.3390/jcm11061638.
Total transferrin concentration changes in acute-phase reactions. Additionally, the alteration of transferrin glycosylation in inflammations can occur. The aim of this study is to evaluate the effect of pancreatitis on the serum profile of transferrin isoforms. The tested groups consisted of 84 patients with acute pancreatitis and 42 patients with chronic hepatitis. Transferrin isoforms were analyzed by capillary electrophoresis on a MINICAP electrophoretic system (Sebia, France). There was a significant decrease in the concentration of pentasialotransferrin in both acute and chronic pancreatitis, and a significant increase in tetrasialotransferrin in the acute pancreatitis group when compared to the control group. There were no significant changes in transferrin isoforms between the acute and chronic pancreatitis groups, and between the edematous and necrotizing forms of the disease. Considering the etiology of acute pancreatitis, we noticed higher values of bile acids and γ-glutamyltransferase in acute pancreatitis of alcoholic etiology than that in pancreatitis of other etiologies. In conclusion, the alterations in transferrin isoform profile in acute and chronic pancreatitis are not organ specific. Because similar changes were observed in hepatitis, we can conclude that the serum profile of transferrin isoforms is involved in the pathogenesis of the disease.
急性期反应中总转铁蛋白浓度的变化。此外，炎症中还可能发生转铁蛋白糖基化的改变。本研究的目的是评估胰腺炎对转铁蛋白异构体血清谱的影响。测试组包括84例急性胰腺炎患者和42例慢性肝炎患者。使用MINICAP电泳系统（法国Sebia公司）通过毛细管电泳分析转铁蛋白异构体。与对照组相比，急性和慢性胰腺炎患者的五唾液酸转铁蛋白浓度均显著降低，急性胰腺炎组的四唾液酸转铁蛋白浓度显著升高。急性胰腺炎组和慢性胰腺炎组之间，以及疾病的水肿型和坏死型之间，转铁蛋白异构体均无显著变化。考虑到急性胰腺炎的病因，我们注意到酒精性病因的急性胰腺炎患者的胆汁酸和γ-谷氨酰转移酶值高于其他病因的胰腺炎患者。总之，急性和慢性胰腺炎中转铁蛋白异构体谱的改变并非器官特异性的。由于在肝炎中也观察到类似变化，我们可以得出结论，转铁蛋白异构体的血清谱参与了疾病的发病机制。
