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不同 Inc 群质粒在中国东北猪、鸡和奶牛源大肠杆菌中的传播与fosfomycin 耐药基因有关。

Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China.

机构信息

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.

Institute of Microbiology and Epizootics, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

出版信息

Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00859-17. Print 2017 Sep.

DOI:10.1128/AAC.00859-17
PMID:28674050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5571358/
Abstract

Thirty-nine fosfomycin-resistant isolates carrying were obtained from pigs, chickens, dairy cows, and staff in four northeastern provinces of China between June 2015 and April 2016. The gene was colocated with genes on conjugative plasmids of the incompatibility groups IncN ( = 12), IncN-F33:A:B( = 2), IncF33:A:B( = 14), IncF14:A:B( = 2), and IncI1/sequence type 136 (ST136) ( = 9). Four different genetic contexts of were detected among the 39 isolates. Three potential epidemic plasmids circulated among strains from this region.

摘要

从 2015 年 6 月至 2016 年 4 月，在中国东北的四个省份，从猪、鸡、奶牛和工作人员中获得了 39 株携带 基因的磷霉素耐药株。该 基因位于可移动质粒上，其不相容群为 IncN（12 株）、IncN-F33:A:B（2 株）、IncF33:A:B（14 株）、IncF14:A:B（2 株）和 IncI1/序列类型 136（ST136）（9 株）。在 39 株分离株中检测到了 基因的 4 种不同的遗传结构。在该地区的 菌株中存在 4 种不同的遗传结构。在该地区的 菌株中，有 3 种潜在的流行质粒在传播。

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