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本文引用的文献

1
High prevalence of bla(CTX-M) extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China.宠物源大肠杆菌中 bla(CTX-M) 型超广谱β-内酰胺酶基因的高流行率及 CTX-M-64 在我国的出现。
Clin Microbiol Infect. 2010 Sep;16(9):1475-81. doi: 10.1111/j.1469-0691.2010.03127.x.
2
Identification of a novel fosfomycin resistance gene (fosA2) in Enterobacter cloacae from the Salmon River, Canada.在加拿大 Salmon 河的阴沟肠杆菌中发现一种新型磷霉素耐药基因（fosA2）。
Lett Appl Microbiol. 2011 Apr;52(4):427-9. doi: 10.1111/j.1472-765X.2011.03016.x. Epub 2011 Feb 21.
3
International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.国际临床实践指南：女性急性单纯性膀胱炎和肾盂肾炎的治疗（2010 年更新）：美国传染病学会和欧洲临床微生物学和传染病学会。
Clin Infect Dis. 2011 Mar 1;52(5):e103-20. doi: 10.1093/cid/ciq257.
4
In vitro susceptibilities of clinical isolates of ertapenem-non-susceptible Enterobacteriaceae to nemonoxacin, tigecycline, fosfomycin and other antimicrobial agents.耐厄他培南肠杆菌科临床分离株对奈诺沙星、替加环素、磷霉素及其他抗菌药物的体外敏感性
Int J Antimicrob Agents. 2011 Mar;37(3):276-8. doi: 10.1016/j.ijantimicag.2010.12.003. Epub 2011 Jan 26.
5
In vitro susceptibility of canine and feline Escherichia coli to fosfomycin.犬和猫大肠埃希菌对磷霉素的体外敏感性。
Vet Microbiol. 2011 Apr 21;149(1-2):277-82. doi: 10.1016/j.vetmic.2010.10.025. Epub 2010 Nov 9.
6
Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants.携带毒力和耐药决定因子的 IncF 质粒的复制子序列分型。
J Antimicrob Chemother. 2010 Dec;65(12):2518-29. doi: 10.1093/jac/dkq347. Epub 2010 Oct 8.
7
Extended-spectrum [beta]-lactamase producing Escherichia coli: changing epidemiology and clinical impact.产超广谱β-内酰胺酶大肠埃希菌：不断变化的流行病学和临床影响。
Curr Opin Infect Dis. 2010 Aug;23(4):320-6. doi: 10.1097/qco.0b013e3283398dc1.
8
Antimicrobial resistance in Escherichia coli isolates from food animals, animal food products and companion animals in China.中国食源性动物、动物食品和伴侣动物中大肠杆菌分离株的抗微生物药物耐药性。
Vet Microbiol. 2010 Nov 20;146(1-2):85-9. doi: 10.1016/j.vetmic.2010.04.025. Epub 2010 May 5.
9
Antimicrobial susceptibility of Gram-negative nonurinary bacteria to fosfomycin and other antimicrobials.革兰氏阴性非尿细菌对磷霉素和其他抗菌药物的药敏性。
Future Microbiol. 2010 Jun;5(6):961-70. doi: 10.2217/fmb.10.47.
10
Molecular characterization of addiction systems of plasmids encoding extended-spectrum beta-lactamases in Escherichia coli.大肠杆菌中编码超广谱β-内酰胺酶的质粒的成瘾系统的分子特征。
J Antimicrob Chemother. 2010 Aug;65(8):1599-603. doi: 10.1093/jac/dkq181. Epub 2010 May 27.

中国宠物源大肠杆菌中携带 fosA3 耐药基因、CTX-M 型β-内酰胺酶基因和 rmtB 的 IncFII 型质粒的传播。

Dissemination of the fosfomycin resistance gene fosA3 with CTX-M β-lactamase genes and rmtB carried on IncFII plasmids among Escherichia coli isolates from pets in China.

机构信息

College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues, South China Agricultural University, Guangzhou, China.

出版信息

Antimicrob Agents Chemother. 2012 Apr;56(4):2135-8. doi: 10.1128/AAC.05104-11. Epub 2012 Jan 9.

DOI:10.1128/AAC.05104-11
PMID:22232290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318358/
Abstract

The presence and characterization of plasmid-mediated fosfomycin resistance determinants among Escherichia coli isolates collected from pets in China between 2006 and 2010 were investigated. Twenty-nine isolates (9.0%) were positive for fosA3, and all of them were CTX-M producers. The fosA3 genes were flanked by IS26 and were localized on F2:A-:B- plasmids or on very similar F33:A-:B- plasmids carrying both bla(CTX-M-65) and rmtB. These findings indicate that the fosA3 gene may be coselected by antimicrobials other than fosfomycin.

摘要

研究了 2006 年至 2010 年间从中国宠物中分离的大肠杆菌中存在的质粒介导磷霉素耐药决定因素及其特征。29 株（9.0%）分离株呈 fosA3 阳性，均为 CTX-M 生产者。fosA3 基因位于 IS26 两侧，位于 F2:A-:B- 质粒或非常相似的 F33:A-:B- 质粒上，这些质粒携带 bla(CTX-M-65)和 rmtB。这些发现表明 fosA3 基因可能与除磷霉素以外的其他抗生素共同选择。