Park Gyujin, Horie Tetsuhiro, Fukasawa Kazuya, Ozaki Kakeru, Onishi Yuki, Kanayama Takashi, Iezaki Takashi, Kaneda Katsuyuki, Sugiura Minoru, Hinoi Eiichi
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School.
Venture Business Laboratory, Organization of Frontier Science and Innovation, Kanazawa University.
Biol Pharm Bull. 2017;40(7):1116-1120. doi: 10.1248/bpb.b17-00161.
β-Cryptoxanthin, which is primarily obtained from citrus fruits such as Satsuma mandarins, is a major carotenoid routinely found in human serum. Recently, we demonstrated that daily oral intake of β-cryptoxanthin prevented ovariectomy-induced bone loss and ameliorated neuropathic pain in mice. Although β-cryptoxanthin exerts preventive effects on various lifestyle-related diseases, there have been no studies on the effect of β-cryptoxanthin on the development of osteoarthritis, the most common degenerative joint disease, which frequently leads to loss of ability and stiffness in the elderly. Here we showed that daily oral administration of β-cryptoxanthin significantly prevented the development of osteoarthritis developed by surgically inducing knee joint instability in mice in vivo. Furthermore, in vitro experiments revealed that β-cryptoxanthin markedly inhibited the expression of inflammatory cytokines and enzymes critical for the degradation of the extracellular matrix in primary chondrocytes. Our results suggest that oral supplementation of β-cryptoxanthin would be beneficial for the maintenance of joint health and as prophylaxis against osteoarthritis.
β-隐黄质主要从温州蜜柑等柑橘类水果中获取，是人体血清中常见的主要类胡萝卜素。最近，我们证明每日口服β-隐黄质可预防卵巢切除诱导的骨质流失，并改善小鼠的神经性疼痛。尽管β-隐黄质对各种与生活方式相关的疾病具有预防作用，但尚无关于β-隐黄质对骨关节炎（最常见的退行性关节疾病，常导致老年人能力丧失和关节僵硬）发展影响的研究。在此我们表明，每日口服β-隐黄质可显著预防通过手术诱导小鼠膝关节不稳在体内发展而来的骨关节炎。此外，体外实验显示β-隐黄质显著抑制原代软骨细胞中对细胞外基质降解至关重要的炎性细胞因子和酶的表达。我们的结果表明，口服补充β-隐黄质对维持关节健康和预防骨关节炎有益。
