Lyu Jiajun, Kubo Takuya, Iwahashi Sayuki, Fukasawa Kazuya, Horie Tetsuhiro, Nagamatsu Katashi, Ikeno Kumiko, Nakamura Genjiro, Kamakura Masaki, Hinoi Eiichi
Department of Bioactive Molecules, Pharmacology, Gifu Pharmaceutical University.
R&D Division, MORIKAWA KENKODO Co. Ltd.
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.
Royal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revealed that raw RJ significantly reduced the expression of inflammatory cytokines and enzymes critical for the degradation of the extracellular matrix (ECM). Similar results were observed after treatment with 10-hydroxy-2-decenoic acid, the most abundant and unique fatty acid in raw RJ. Our results suggest that oral supplementation with RJ would benefit the maintenance of joint health and prophylaxis against OA, possibly by suppressing the activity of inflammatory cytokines and ECM-degrading enzymes.
蜂王浆（RJ）是蜂王的必需食物，具有多种生物活性。尽管蜂王浆对各种与生活方式相关的疾病，如骨质疏松症和肥胖症具有预防作用，但尚无研究评估蜂王浆对骨关节炎（OA）——最常见的退行性关节疾病——发展的影响。在此，我们表明，在小鼠手术诱导膝关节不稳定后，每日口服生蜂王浆可显著预防体内骨关节炎的发展。此外，使用软骨细胞的体外实验表明，生蜂王浆可显著降低炎症细胞因子和对细胞外基质（ECM）降解至关重要的酶的表达。在用10-羟基-2-癸烯酸（生蜂王浆中含量最丰富且独特的脂肪酸）处理后，观察到了类似结果。我们的结果表明，口服补充蜂王浆可能通过抑制炎症细胞因子和ECM降解酶的活性，有益于维持关节健康和预防骨关节炎。
