Utari Putri D, Vogel Jan, Quax Wim J
Chemical and Pharmaceutical Biology Department, University of GroningenGroningen, Netherlands.
Front Microbiol. 2017 Jun 19;8:1123. doi: 10.3389/fmicb.2017.01123. eCollection 2017.
-Acylhomoserine lactone (AHL)-acylase (also known as amidase or amidohydrolase) is a class of enzyme that belongs to the Ntn-hydrolase superfamily. As the name implies, AHL-acylases are capable of hydrolysing AHLs, the most studied signaling molecules for quorum sensing in Gram-negative bacteria. Enzymatic degradation of AHLs can be beneficial in attenuating bacterial virulence, which can be exploited as a novel approach to fight infection of human pathogens, phytopathogens or aquaculture-related contaminations. Numerous acylases from both prokaryotic and eukaryotic sources have been characterized and tested for the interference of quorum sensing-regulated functions. The existence of AHL-acylases in a multitude of organisms from various ecological niches, raises the question of what the physiological roles of AHL-acylases actually are. In this review, we attempt to bring together recent studies to extend our understanding of the biological functions of these enzymes in nature.
-酰基高丝氨酸内酯（AHL）酰基酶（也称为酰胺酶或酰胺水解酶）是一类属于Ntn水解酶超家族的酶。顾名思义，AHL酰基酶能够水解AHL，AHL是革兰氏阴性菌群体感应中研究最多的信号分子。AHL的酶促降解在减弱细菌毒力方面可能是有益的，这可以作为对抗人类病原体、植物病原体或水产养殖相关污染物感染的一种新方法加以利用。来自原核和真核生物来源的众多酰基酶已被鉴定并测试其对群体感应调节功能的干扰。在来自各种生态位的多种生物体中存在AHL酰基酶，这就引发了一个问题，即AHL酰基酶的实际生理作用是什么。在这篇综述中，我们试图汇集最近的研究，以扩展我们对这些酶在自然界中生物学功能的理解。
