Davis Jennifer S, Lee Hwa Young, Kim Jihye, Advani Shailesh M, Peng Ho-Lan, Banfield Emilyn, Hawk Ernest T, Chang Shine, Frazier-Wood Alexis C
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA.
Open Heart. 2017 Apr 28;4(1):e000550. doi: 10.1136/openhrt-2016-000550. eCollection 2017.
Aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are preventive against cardiovascular disease (CVD) and several cancer types, but long-term use has been associated with significant health risks, resulting in conflicting recommendations on NSAID use for prevention of CVD and cancer. Previous research indicates that aspirin use increases with age and CVD risk factors and that a large percentage of the US population regularly use analgesics, including NSAIDs, but there has not been a recent, in-depth assessment of NSAID use prevalence, changes in use over time or predictors of NSAID use in the USA.
We used the cross-sectional, National Health And Nutrition Examination Survey (NHANES) from 1988 to 1994 and three continuous cycles (1999-2004) to assess regular NSAID use prevalence, changes over time and predictors of regular NSAID use.
Overall, regular NSAID use increased over time and varied by demographic features. Participants over 60 years of age, women, participants with high body mass index, increased waist circumference or heart disease were significantly more likely to be regular NSAID users. By contrast, non-Hispanic African American and Mexican American participants were significantly less likely to regularly use NSAIDs.
This study uses a nationally representative data set (NHANES) to provide an exploration of regular NSAID use patterns over time, highlighting several demographic, lifestyle and clinical conditions associated with regular NSAID use. Understanding who is likely to regularly use NSAIDs enables more targeted messaging both for increasing the preventive benefits and for limiting the toxicities associated with regular use of NSAIDs.
阿司匹林和非阿司匹林类非甾体抗炎药（NSAIDs）可预防心血管疾病（CVD）和多种癌症，但长期使用与重大健康风险相关，导致关于NSAIDs用于预防CVD和癌症的建议相互矛盾。先前的研究表明，阿司匹林的使用随年龄和CVD风险因素增加，且美国很大一部分人口经常使用镇痛药，包括NSAIDs，但近期尚未对美国NSAIDs的使用 prevalence、随时间的使用变化或NSAIDs使用的预测因素进行深入评估。
我们使用了1988年至1994年的横断面全国健康与营养检查调查（NHANES）以及三个连续周期（1999 - 2004年）来评估NSAIDs的常规使用 prevalence、随时间的变化以及NSAIDs常规使用的预测因素。
总体而言，NSAIDs的常规使用随时间增加，且因人口统计学特征而异。60岁以上的参与者、女性、体重指数高、腰围增加或患有心脏病的参与者更有可能成为NSAIDs的常规使用者。相比之下，非西班牙裔非洲裔美国人和墨西哥裔美国人定期使用NSAIDs的可能性显著较低。
本研究使用具有全国代表性的数据集（NHANES）来探讨NSAIDs随时间的常规使用模式，突出了与NSAIDs常规使用相关的几个人口统计学、生活方式和临床状况。了解哪些人可能经常使用NSAIDs有助于更有针对性地传达信息，既增加预防益处，又限制与NSAIDs常规使用相关的毒性。
