Lili Yu, Jian Ma, Junpeng Gao, Kun Zhai, Jinfang Zhu, Yongqing Huang
College of Stomatology, Ningxia Medical University, Yinchuan 750004, China.
Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):291-295. doi: 10.7518/hxkq.2017.03.012.
To investigate the association between non-syndromic cleft lip with or without cleft palate (NSCL/P) and environmental factors in Ningxia population.
This case-control study involved 453 NSCL/P patients and 452 normal newborns from Ningxia. A questionnaire focusing on various factors, including family history, pregnancy reaction, drug use during pregnancy, and infections, was used and responses were analyzed through Chi-square test and Logistic regression analysis with SPSS 16.0.
The constituent ratio of different types of NSCL/P was cleft lip∶cleft lip and palate∶cleft palate equal to 1︰2.02︰1.51. Logistic regression analysis revealed that abnormal pregnancy, infection, abortion, drugs, drinking, smoking, and living near factories likely increased the risk of NSCL/P (P<0.05). Single fetus, pregnancy-related nausea, vomiting, parents' moderate tastes, and eating soy foods and fruits decreased the risk of NSCL/P (P<0.05).
CONCLUSIONS: The incidence of NSCL/P should be reduced to enhance the conditions of women during pregnancy by maintaining a balanced diet and avoiding infections, abortion, drugs, and negative habits. .
探讨宁夏人群非综合征性唇腭裂（NSCL/P）与环境因素之间的关联。
本病例对照研究纳入了453例来自宁夏的NSCL/P患者和452例正常新生儿。使用一份聚焦于多种因素的问卷，包括家族史、妊娠反应、孕期用药及感染情况等，并运用SPSS 16.0软件通过卡方检验和Logistic回归分析对所得回答进行分析。
不同类型NSCL/P的构成比为唇裂∶唇腭裂∶腭裂 = 1∶2.02∶1.51。Logistic回归分析显示，异常妊娠、感染、流产、用药、饮酒、吸烟及居住在工厂附近可能会增加NSCL/P的发病风险（P<0.05）。单胎妊娠、妊娠相关的恶心、呕吐、父母口味适中以及食用豆制品和水果会降低NSCL/P的发病风险（P<0.05）。
应通过保持均衡饮食、避免感染、流产、用药及不良习惯来改善孕期女性状况，从而降低NSCL/P的发病率。
