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CD44和CD133表达在口腔潜在恶性疾病及口腔鳞状细胞癌中的临床意义

[Clinical significance of CD44 and CD133 expression in oral potentially malignant disorder and oral squamous cell carcinoma].

作者信息

Jiajia Qi, Yan Sun, Changqing Yuan, Wenjing Jiang, Han Zhao, Yuanpan Cao, Qiuyan Liu

机构信息

School of Stomatology, Qingdao University, Qingdao 266000, China.

Dept. of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun 1;35(3):311-316. doi: 10.7518/hxkq.2017.03.015.

DOI:10.7518/hxkq.2017.03.015
PMID:28675018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7030429/
Abstract

OBJECTIVE

This study aims to investigate the expression and relationship of CD44 and CD133 in normal oral mucosa, oral potentially malignant disorder (OPMD), and oral squamous cell carcinoma (OSCC). This work also analyzes the relationship between such expression and clinical factors. This study intends to evaluate the clinical value of using CD44 and CD133 as indices to evaluate the carcinogenic potential of OPMD.

METHODS

Clinical data from 60 patients with OPMD, 60 patients with OSCC, and 10 cases of normal oral mucosa were analyzed. Double immunohistochemical analysis was applied to investigate the expression of CD44 and CD133 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues. Subsequently, the relationships between such expression and clinical factors were analyzed.

RESULTS

The positive rates of CD44 expression in the normal oral mucosa, OPMD, and OSCC tissues were 100.00%, 96.67%, and 71.67% (P<0.05), respectively. Meanwhile, the positive rates of CD133 expression in the normal oral mucosa, OPMD, and OSCC tissues were 0.00%, 35.00%, and 63.33% (P<0.05), respectively. The expression of CD44 and CD133 was found to be correlated (P<0.05). Such expression was related to the clinical stages and lymphatic metastasis of OSCC (P<0.05).

CONCLUSIONS: CD44 and CD133 can be used individually as clinical indices to evaluate the carcinogenic potential of OPMD.
.

摘要

目的

本研究旨在探讨CD44和CD133在正常口腔黏膜、口腔潜在恶性病变（OPMD）及口腔鳞状细胞癌（OSCC）中的表达及相关性。本研究还分析了这种表达与临床因素之间的关系。本研究旨在评估将CD44和CD133作为评估OPMD致癌潜能指标的临床价值。

方法

分析60例OPMD患者、60例OSCC患者及10例正常口腔黏膜患者的临床资料。采用双重免疫组织化学分析法研究正常口腔黏膜、OPMD及OSCC组织石蜡切片中CD44和CD133的表达。随后，分析这种表达与临床因素之间的关系。

结果

正常口腔黏膜、OPMD及OSCC组织中CD44表达的阳性率分别为100.00%、96.67%和71.67%（P<0.05）。同时，正常口腔黏膜、OPMD及OSCC组织中CD133表达的阳性率分别为0.00%、35.00%和63.33%（P<0.05）。发现CD44和CD133的表达具有相关性（P<0.05）。这种表达与OSCC的临床分期及淋巴转移有关（P<0.05）。

结论

CD44和CD133可单独作为评估OPMD致癌潜能的临床指标。