Goldstuck Norman D
a Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences , University of Stellenbosch, Belleville , Western Cape , South Africa.
Expert Rev Med Devices. 2017 Aug;14(8):593-599. doi: 10.1080/17434440.2017.1350169. Epub 2017 Jul 11.
Jaydess/Skyla and Kyleena are 'low dose' levonorgestrel releasing intrauterine systems(LNG-IUS). They differ from Mirena and other similar LNG-IUSs in terms of pharmacological properties and physical dimensions. There are currently no defined guidelines to decide when to use Jaydess or Kyleena or Mirena. Areas covered: MEDLINE, POPLINE, PubMed and clinicaltrials.gov were searched using the terms 'Jaydess', 'Skyla', LNG-IUS 13.5mg and 'Kyleena' LNG-IUS 19.5mg. Only clinical research articles as opposed to generalised reviews and opinion papers on the newer LNG-IUSs were considered for review. There were 10 clinical research articles and 11 clinical research abstracts relating to Jaydess/Skyla(LNG-IUS13.5mg) and Kyleena(LNG-IUS 19.5mg). All the studies were sponsored by the manufacturer. There were no independent clinical research studies. Expert commentary: The clinical research information from studies on Jaydess/Skyla and Kyleena does not adequately inform the clinician when and where these IUSs should be used in preference to other LNG-containing IUSs. The terminology used for describing the new low dose LNG-IUSs is inconsistent. The clinical differences between Jaydess, Kyleena and Mirena and the clinical differences in parity of subjects using Jaydess or Kyleena is used to generate an algorithm for helping clinicians choose between Mirena and Jaydess/Skyla or Kyleena.
杰德丝/斯凯拉和凯丽娜是“低剂量”左炔诺孕酮宫内节育系统（LNG-IUS）。它们在药理特性和物理尺寸方面与曼月乐及其他类似的LNG-IUS有所不同。目前尚无明确的指南来决定何时使用杰德丝、凯丽娜或曼月乐。涵盖领域：使用“杰德丝”“斯凯拉”“13.5毫克LNG-IUS”和“19.5毫克凯丽娜LNG-IUS”等术语对MEDLINE、POPLINE、PubMed和临床试验.gov进行了检索。仅纳入了关于新型LNG-IUS的临床研究文章，而非一般性综述和观点论文以供审查。有10篇临床研究文章和11篇临床研究摘要涉及杰德丝/斯凯拉（13.5毫克LNG-IUS）和凯丽娜（19.5毫克LNG-IUS）。所有研究均由制造商赞助。没有独立的临床研究。专家评论：关于杰德丝/斯凯拉和凯丽娜的临床研究信息并未充分告知临床医生在何时何地应优先于其他含LNG的IUS使用这些IUS。用于描述新型低剂量LNG-IUS的术语并不一致。利用杰德丝、凯丽娜与曼月乐之间的临床差异以及使用杰德丝或凯丽娜的受试者在产次上的临床差异，生成了一种算法，以帮助临床医生在曼月乐与杰德丝/斯凯拉或凯丽娜之间做出选择。
