Wang Yuzhou, Zhou Yijin, Yang Zhicheng, Chen Baoying, Huang Wennan, Liu Yongyuan, Zhang Ying
Oncology Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
Tumour Biol. 2017 Jul;39(7):1010428317690998. doi: 10.1177/1010428317690998.
Long non-coding RNAs recently were identified as key mediators of cancer metastasis. This study provided evidence that long non-coding RNA MALAT1 was up-regulated in breast cancer tissues and cell lines. MALAT1 promoted cancer cell invasion through inducing epithelial-mesenchymal transition. Interestingly, we revealed there was a reciprocal repression between MALAT1 and miR-204. ZEB2 was identified as a downstream target of miR-204 and MALAT1 exerted its function mainly through the miR-204/ZEB2 axis. Our findings suggested that MALAT1 may serve as a new diagnostic biomarker and therapy target for breast cancer.
长链非编码RNA最近被确定为癌症转移的关键介质。这项研究提供了证据，表明长链非编码RNA MALAT1在乳腺癌组织和细胞系中上调。MALAT1通过诱导上皮-间质转化促进癌细胞侵袭。有趣的是，我们发现MALAT1和miR-204之间存在相互抑制作用。ZEB2被确定为miR-204的下游靶点，MALAT1主要通过miR-204/ZEB2轴发挥其功能。我们的研究结果表明，MALAT1可能作为乳腺癌的一种新的诊断生物标志物和治疗靶点。
