基于免疫受体酪氨酸的抑制性基序（ITIM）的酶促自组装。
Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM).
作者信息
Yamagata Natsuko, Chen Xiaoyi, Zhou Jie, Li Jie, Du Xuewen, Xu Bing
机构信息
Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.
出版信息
Org Biomol Chem. 2017 Jul 21;15(27):5689-5692. doi: 10.1039/c7ob01074e. Epub 2017 Jul 4.
Abstract
Here we show the first example of an immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, to self-assemble in water via enzyme-instructed self-assembly. Upon enzymatic dephosphorylation, the phosphohexapeptides become hexapeptides, which self-assemble in water to result in supramolecular hydrogels. This work illustrates a new approach to design bioinspired soft materials from a less explored, but important pool of immunomodulatory peptides.
摘要
在此，我们展示了首个基于免疫受体酪氨酸的抑制性基序（ITIM）——LYYYYL，及其对映体或逆序肽通过酶促自组装在水中自组装的实例。经酶促去磷酸化后，磷酸化六肽变成六肽，其在水中自组装形成超分子水凝胶。这项工作阐明了一种从研究较少但重要的免疫调节肽库中设计受生物启发的软材料的新方法。
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