用于生物医学应用的超分子软物质的酶促非共价合成。
Enzymatic Noncovalent Synthesis of Supramolecular Soft Matter for Biomedical Applications.
作者信息
Shy Adrianna N, Kim Beom Jin, Xu Bing
机构信息
Department of Chemistry, Brandeis University, Waltham, MA 02453, USA.
出版信息
Matter. 2019 Nov 6;1(5):1127-1147. doi: 10.1016/j.matt.2019.09.015.
Enzymatic noncovalent synthesis (ENS), a process that integrates enzymatic reactions and supramolecular (i.e., noncovalent) interactions for spatial organization of higher-order molecular assemblies, represents an emerging research area at the interface of physical and biological sciences. This review provides a few representative examples of ENS in the context of supramolecular soft matter. After a brief comparison of enzymatic covalent and noncovalent synthesis, we discuss ENS of man-made molecules for generating supramolecular nanostructures (e.g., supramolecular hydrogels) in cell-free conditions. Then, we introduce ENS in a cellular environment. To illustrate the unique merits for applications, we discuss intercellular, peri- or intracellular, and subcellular ENS for cell morphogenesis, molecular imaging, cancer therapy, and targeted delivery. Finally, we provide an outlook on the potential of ENS. We hope that this review offers a new perspective for scientists who develop supramolecular soft matter to address societal needs at various frontiers.
酶促非共价合成（ENS）是一种将酶促反应与超分子（即非共价）相互作用相结合以实现高阶分子组装体空间组织的过程，它代表了物理科学与生物科学交叉领域中一个新兴的研究领域。本综述提供了一些超分子软物质背景下酶促非共价合成的代表性实例。在简要比较酶促共价合成和非共价合成之后，我们讨论了在无细胞条件下用于生成超分子纳米结构（如超分子水凝胶）的人造分子的酶促非共价合成。然后，我们介绍细胞环境中的酶促非共价合成。为了说明其应用的独特优点，我们讨论了用于细胞形态发生、分子成像、癌症治疗和靶向递送的细胞间、细胞周或细胞内以及亚细胞酶促非共价合成。最后，我们对酶促非共价合成的潜力进行了展望。我们希望这篇综述为开发超分子软物质以满足各个前沿领域社会需求的科学家提供一个新的视角。
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