Koo M W, Ogle C W, Cho C H
Pharmacol Biochem Behav. 1985 Dec;23(6):969-72. doi: 10.1016/0091-3057(85)90102-9.
The effects of drug treatment and of cold-restraint stress (a method used to produce experimental stomach ulcers) on gastric emptying of a resin (colestipol-phenol red complex) were investigated in rats. Gastric emptying was decreased by intraperitoneal treatment with atropine (0.3 mg/kg) or verapamil (4 mg/kg), and enhanced by bethanechol (1.2 mg/kg). Stress by restraint at 4 degrees C for 2 hr markedly reduced gastric emptying; the pattern of effects of drug pretreatment in these stressed rats was similar to that seen in their nonstressed controls. Further experiments, with stress for 3 hr, revealed that the gastric emptying rate was triphasic; increasing in the first hr, returning to normal and then slowing in the third hr of stress. Initial increase in emptying rate was probably due to predominant vagal overactivity. Hypothermia and possibly other factors induced by cold-restraint stress could have subsequently depressed gastric motility.
研究了药物治疗以及冷束缚应激（一种用于制造实验性胃溃疡的方法）对大鼠胃排空树脂（考来替泊-酚红复合物）的影响。腹腔注射阿托品（0.3毫克/千克）或维拉帕米（4毫克/千克）可使胃排空减慢，而注射氨甲酰甲胆碱（1.2毫克/千克）则可使胃排空加快。在4摄氏度下束缚2小时所产生的应激显著降低了胃排空；在这些应激大鼠中，药物预处理的效果模式与其非应激对照相似。进一步的实验表明，应激3小时时胃排空率呈三相变化；在应激的第1小时增加，恢复正常，然后在第3小时减慢。排空率最初的增加可能是由于迷走神经活动占主导。冷束缚应激诱导的体温过低以及可能的其他因素随后可能抑制了胃动力。
