Qiu B S, Cho C H, Ogle C W
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Experientia. 1992 Apr 15;48(4):389-91. doi: 10.1007/BF01923437.
Ten-day treatment with nicotine (5, 25 or 50 micrograms/ml drinking water) dose-dependently intensified gastric ulceration induced by cold-restraint, and emptying rate. Stomach contractions produced by graded doses of bethanechol i.v. were elevated further by nicotine treatment. It is suggested that chronic nicotine administration produces hypersensitivity of the gastric muscarinic receptors; stomach hypermotility contributes to the ulcer-worsening action of the alkaloid.
