Research Institute & Department of Chemistry, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India.
Research Institute & Department of Chemistry, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India.
Biosens Bioelectron. 2018 Apr 30;103:113-129. doi: 10.1016/j.bios.2017.12.031. Epub 2017 Dec 22.
Introduction of novel functional nanomaterials and analytical technologies signify a foremost possibility for the advance of electrochemical sensor and biosensor platforms/devices for a broad series of applications including biological, biomedical, biotechnological, clinical and medical diagnostics, environmental and health monitoring, and food industries. The design of sensitive and selective electrochemical biological sensor platforms are accomplished conceivably by offering new surface modifications, microfabrication techniques, and diverse nanomaterials with unique properties for in vivo and in vitro medical analysis via relating a sensibly planned electrode/solution interface. The advantageous attributes such as low-cost, miniaturization, energy efficient, easy fabrication, online monitoring, and the simultaneous sensing capability are the driving force towards continued growth of electrochemical biosensing platforms, which have fascinated the interdisciplinary research arenas spanning chemistry, material science, biological science, and medical industries. The electrochemical biosensor platforms have potential applications in the early-stage detection and diagnosis of disease as stout and tunable diagnostic and therapeutic systems. The key aim of this review is to emphasize the newest development in the design of sensing and biosensing platforms based on functional nanomaterials for biological and biomedical applications. High sensitivity and selectivity, fast response, and excellent durability in biological media are all critical aspects which will also be wisely addressed. Potential applications of electrochemical sensor and biosensor platforms based on advanced functional nanomaterials for neuroscience diagnostics, clinical, point-of-care diagnostics and medical industries are also concisely presented.
介绍新型功能纳米材料和分析技术，为电化学传感器和生物传感器平台/设备的发展提供了首要可能性，这些平台/设备可应用于广泛的领域，包括生物、生物医学、生物技术、临床和医学诊断、环境和健康监测以及食品工业。通过合理设计电极/溶液界面，可以实现对敏感和选择性电化学生物传感器平台的设计，提供新的表面修饰、微制造技术和具有独特性能的各种纳米材料，用于体内和体外的医学分析。低成本、小型化、节能、易于制造、在线监测和同时感测能力等优势特性是电化学生物传感平台持续发展的驱动力，这吸引了跨越化学、材料科学、生物科学和医学领域的跨学科研究领域。电化学生物传感器平台在疾病的早期检测和诊断方面具有潜在的应用，作为坚固和可调的诊断和治疗系统。本文的主要目的是强调基于功能纳米材料的传感和生物传感平台设计的最新发展，用于生物和生物医学应用。高灵敏度和选择性、快速响应和在生物介质中的出色耐用性都是需要明智解决的关键方面。本文还简要介绍了基于先进功能纳米材料的电化学传感器和生物传感器平台在神经科学诊断、临床、即时诊断和医学领域的潜在应用。
