Khan Haroon, Khan Ziyad, Amin Surriya, Mabkhot Yahia Nasser, Mubarak Mohammad S, Hadda Taibi Ben, Maione Francesco
Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Pakistan.
Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Pakistan.
Biomed Pharmacother. 2017 Sep;93:498-509. doi: 10.1016/j.biopha.2017.06.077. Epub 2017 Jul 1.
Despite therapeutic advancement in the treatment of fungal infections, morbidity and mortality caused by these infections are still very high. There are approximately 300 fungal species that are infectious and can cause a variety of diseases. At present, several synthetic antifungal drugs are in clinical practice, many of them, however, are vulnerable to multidrug-resistant strains of microbes, and thus compromising the overall treatment outcomes. Glycosides are naturally occurring plant secondary metabolites with important therapeutic potential and clinical utility. The aim of this review was to focus on the antifungal effects of glycosides in preclinical studies with possible mechanism(s) wherein described. Published research show significant susceptibility of different fungi towards phytoglycosides, mediated through multiple mechanisms. Further detailed studies are needed to explain the clinical applications and limitations of these glycosides.
尽管在真菌感染的治疗方面取得了治疗进展，但这些感染所导致的发病率和死亡率仍然很高。大约有300种具有传染性的真菌物种，它们可引发多种疾病。目前，有几种合成抗真菌药物在临床中使用，然而，其中许多药物易受微生物多重耐药菌株的影响，从而影响整体治疗效果。糖苷是天然存在的植物次生代谢产物，具有重要的治疗潜力和临床应用价值。本综述的目的是关注糖苷在临床前研究中的抗真菌作用及其可能的作用机制。已发表的研究表明，不同真菌对植物糖苷具有显著的敏感性，这是通过多种机制介导的。需要进一步详细研究来解释这些糖苷的临床应用和局限性。
