Juhi Umme Habiba, El-Nashar Heba A S, Al Faruq Abdullah, Bhuia Md Shimul, Sultana Irin, Alam Syedul, Abuyousef Farah, Saleh Na'il, El-Shazly Mohamed, Islam Muhammad Torequl
Department of Pharmacy, Southern University Bangladesh, Chattogram, Bangladesh.
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Front Pharmacol. 2024 Apr 4;15:1366889. doi: 10.3389/fphar.2024.1366889. eCollection 2024.
is an evergreen ornamental small fern, belonging to the family Pteridaceae, that grows in warm and rocky regions worldwide. Many species of genus are evidently endowed with important phytochemicals and bioactivities. This study aimed to perform a preliminary phytochemical analysis of leaves alongside an evaluation of free radical scavenging, anti-inflammatory, antimicrobial, and clot lysis activities of extract fractions. A preliminary phytochemical analysis was done after fractionation of ethanolic extract (ECT) with -hexane (HCT) and chloroform (CCT). Then, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, egg albumin and RBC membrane stabilization tests, disc diffusion, and human blood clot lysis assays were performed. Phytochemical investigations suggested that the plant is rich in alkaloids, glycosides, tannins, and flavonoids. All obtained fractions exhibited concentration-dependent radical scavenging, inhibition of egg protein denaturation and RBC membrane lysis capacities. Except for antifungal tests, ECT exhibited better DPPH radical scavenging, anti-inflammatory, antibacterial, and clot lysis capacities than HCT and CCT fractions. However, all fractions exhibited a mild anti-inflammatory activity. might be a good source of antioxidant, anti-microbial, and anti-atherothrombotic agents. Further studies are required to isolate and characterize the active principles liable for each bioactivity, along with possible molecular interactions.
是一种常绿观赏小型蕨类植物，属于凤尾蕨科，生长在世界各地温暖的岩石地区。该属的许多物种显然含有重要的植物化学物质和生物活性。本研究旨在对[植物名称]叶进行初步植物化学分析，并评估提取物各部分的自由基清除、抗炎、抗菌和凝块溶解活性。用正己烷（HCT）和氯仿（CCT）对乙醇提取物（ECT）进行分馏后，进行了初步植物化学分析。然后，进行了2,2-二苯基-1-苦基肼（DPPH）自由基清除、蛋清和红细胞膜稳定试验、纸片扩散试验以及人血凝块溶解试验。植物化学研究表明，该植物富含生物碱、糖苷、单宁和黄酮类化合物。所有得到的部分均表现出浓度依赖性的自由基清除、抑制蛋清蛋白变性和红细胞膜溶解能力。除抗真菌试验外，ECT在DPPH自由基清除、抗炎、抗菌和凝块溶解能力方面均优于HCT和CCT部分。然而，所有部分均表现出轻度的抗炎活性。[植物名称]可能是抗氧化剂、抗微生物剂和抗动脉粥样血栓形成剂的良好来源。需要进一步研究分离和鉴定对每种生物活性负责的活性成分以及可能的分子相互作用。
