Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Inokashira Hospital, Tokyo, Japan.
Pharmacopsychiatry. 2017 Nov;50(6):264-269. doi: 10.1055/s-0043-113828. Epub 2017 Jul 4.
Data on the knowledge about antipsychotic medications prescribed in patients with schizophrenia are very limited. Moreover, it remains unclear how patients' knowledge about prescribed antipsychotics affects medication adherence. ighty-one Japanese outpatients with schizophrenia according to the International Classification of Diseases, 10th edition, were included. Patients' knowledge of the primary antipsychotics prescribed to them in terms of therapeutic effects, type, and implicated neurotransmitters was assessed with a multiple-choice questionnaire developed for this study. Medication possession ratios (MPRs) were compared between patients who answered correctly and those who did not in each category. The percentages of subjects who answered correctly regarding antipsychotic effects, type, and implicated neurotransmitters were low at 30.9%, 30.9%, and 7.4%, respectively. No differences were found in MPRs between subjects who answered correctly and those who did not. Our preliminary results indicate that patients lack knowledge about their antipsychotic medications. More concerning, they suggest that knowledge about prescribed antipsychotics may not directly translate into actual medication adherence in patients with schizophrenia.
关于精神分裂症患者所开抗精神病药物的知识的数据非常有限。此外，患者对抗精神病药物的了解如何影响药物依从性仍不清楚。本研究纳入了 81 名根据国际疾病分类第 10 版诊断为精神分裂症的日本门诊患者。使用为这项研究开发的多项选择问卷评估了患者对他们所开的主要抗精神病药物的疗效、类型和涉及的神经递质的了解。比较了每个类别中正确回答和不正确回答的患者的药物持有率（MPR）。正确回答抗精神病药物疗效、类型和涉及的神经递质的患者比例分别为 30.9%、30.9%和 7.4%，较低。正确回答和不正确回答的患者的 MPR 没有差异。我们的初步结果表明，患者对抗精神病药物的了解不足。更令人担忧的是，这表明患者对抗精神病药物的了解可能不会直接转化为精神分裂症患者的实际药物依从性。
