随着时间推移，即使在接受高效抗逆转录病毒治疗（HAART）的情况下，HIV-1感染成人的吞噬作用仍存在缺陷。
Deficient Phagocytosis Among HIV-1 Infected Adults Over Time Even in HAART Setting.
作者信息
Tsachouridou Olga, Skoura Lemonia, Chatzidimitriou Dimitris, Margariti Apostolia, Georgiou Adamantini, Chatzidimitriou Maria, Bougiouklis Dimitrios, Zebekakis Pantelis, Metallidis Symeon
机构信息
1st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1 Stilponos Kyriakidi Str, 54636, Thessaloniki. Greece.
National AIDS Reference Centre of Northern Greece, Medical School, Aristotle University of Thessaloniki, Thessaloniki. Greece.
出版信息
Curr HIV Res. 2017;15(4):285-290. doi: 10.2174/1570162X15666170704101622.
BACKGROUND
Phagocytosis is regarded to be impaired in HIV-1 infected adults, leading to high frequency and severity of several infections in this population. Data is contradictory with regards to individual facets in HIV infection.
OBJECTIVE
Aim of this study was to assess the phagocytic activity during the natural course of HIV infection.
METHOD
It is a longitudinal study assessing natural course and impairment of neutrophil and monocyte phagocytosis in both naïve and HAART treated patients.
RESULTS
A lower neutrophil phagocytic activity was recorded in naïve patients compared to treated patients. Interestingly, a downward trend of neutrophil phagocytic activity was recorded in both groups, irrespectively of HAART intake, within 48 weeks of observation.
CONCLUSION
Defects of innate immunity appear to be present in HIV infected patients regarding phagocytic activity of monocytes and of neutrophils which seems to decline over time. These deficiencies are influenced by the levels of CD4 cell counts and viral load.
背景
吞噬作用在HIV-1感染的成年人中被认为受损，导致该人群中多种感染的高频率和严重性。关于HIV感染中各个方面的数据相互矛盾。
目的
本研究的目的是评估HIV感染自然病程中的吞噬活性。
方法
这是一项纵向研究，评估初治和接受高效抗逆转录病毒治疗（HAART）患者中性粒细胞和单核细胞吞噬作用的自然病程及损害情况。
结果
与接受治疗的患者相比，初治患者的中性粒细胞吞噬活性较低。有趣的是，在观察的48周内，无论是否接受HAART治疗，两组患者的中性粒细胞吞噬活性均呈下降趋势。
结论
就单核细胞和中性粒细胞的吞噬活性而言，HIV感染患者似乎存在先天免疫缺陷，且这种缺陷似乎会随时间推移而下降。这些缺陷受CD4细胞计数和病毒载量水平的影响。
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