Malley L A, Cagen S Z, Parker C M, Gardiner T H, van Gelder G A, Rose G P
Toxicol Lett. 1985 Dec;29(1):51-8. doi: 10.1016/0378-4274(85)90199-7.
Previous investigations have demonstrated that dermal exposure to fenvalerate or other synthetic pyrethroid insecticides can produce a skin sensory response characterized by an itching/tingling sensation in humans and animals. The objective of this investigation performed in guinea pigs was to establish treatments which would be effective against pyrethroid-mediated skin sensation. Two classes of agents were tested. Barrier agents, which block penetration of substances through the skin, did not significantly reduce the fenvalerate-mediated skin sensations. Post-treatments with steroidal Dermolate, antihistamine Delamine or anti-inflammatory aspirin did not significantly reduce the pyrethroid-mediated skin sensation. However, Bicozene (a local anesthetic cream) and Tashan (a vitamin A, D, and E-containing cream) were effective in reducing the pyrethroid-mediated skin sensations. Prior (30 min and 5h) dermal application of vitamin E was found to be effective in significantly reducing the fenvalerate-mediated skin sensation; even when applied 29 h prior to fenvalerate exposure, there appeared to be a reduced skin response. Piperonyl butoxide (PBO), a pesticide synergist, reduced the fenvalerate skin sensations when applied either directly to the skin or in conjunction with the pyrethroid.
先前的研究表明，皮肤接触氰戊菊酯或其他合成拟除虫菊酯类杀虫剂会在人和动物身上产生一种以瘙痒/刺痛感为特征的皮肤感觉反应。在豚鼠身上进行的这项研究的目的是确定对拟除虫菊酯介导的皮肤感觉有效的治疗方法。测试了两类药物。阻隔剂可阻止物质透过皮肤渗透，但并不能显著减轻氰戊菊酯介导的皮肤感觉。使用甾体类药物德莫拉特、抗组胺药德拉明或抗炎药阿司匹林进行后续治疗，也不能显著减轻拟除虫菊酯介导的皮肤感觉。然而，必可松（一种局部麻醉乳膏）和塔山（一种含有维生素A、D和E的乳膏）能有效减轻拟除虫菊酯介导的皮肤感觉。研究发现，预先（30分钟和5小时）经皮涂抹维生素E能显著减轻氰戊菊酯介导的皮肤感觉；即使在接触氰戊菊酯前29小时涂抹，皮肤反应似乎也有所减轻。增效醚（PBO），一种农药增效剂，直接涂抹于皮肤或与拟除虫菊酯联合使用时，可减轻氰戊菊酯引起的皮肤感觉。
